{"doi":"10.1016/j.jacc.2007.11.087","title":"Association of Genetic Variation on Chromosome 9p21 With Susceptibility and Progression of Atherosclerosis","abstract":null,"journal":"Journal of the American College of Cardiology","year":2008,"id":611613,"datarank":0.7574784010874307,"base_score":5.049856007249537,"endowment":5.049856007249537,"self_citation_contribution":0.7574784010874307,"citation_network_contribution":0.0,"self_endowment_contribution":0.7574784010874307,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":155,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":39314,"name":"Johann Willeit","orcid":"0000-0003-4083-0466","position":1,"is_corresponding":false},{"id":2345,"name":"Florian Kronenberg","orcid":"0000-0003-2229-1120","position":2,"is_corresponding":false},{"id":580499,"name":"Qingbo Xu","orcid":"0000-0002-6414-2273","position":3,"is_corresponding":false},{"id":38821,"name":"Stefan Kiechl","orcid":null,"position":4,"is_corresponding":false},{"id":15846,"name":"Shu Ye","orcid":"0000-0002-4126-4278","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Association of Genetic Variation on Chromosome 9p21 With Susceptibility and Progression of Atherosclerosis","abstract":"<h4>Objectives</h4>Following the recent novel finding from genomewide association studies that sequence variation on chromosome 9p21 is a genetic factor for coronary artery disease, we investigated whether the genetic variant influenced the development of atherosclerosis and its progression in a population-based, prospective study.<h4>Background</h4>Recently, several genomewide association studies revealed a highly significant association between variation on chromosome 9p21 and risk of coronary artery disease.<h4>Methods</h4>We studied the rs1333049 polymorphism located on chromosome 9p21 in a cohort of 769 individuals who participated in the Bruneck study with long-term follow-up data on carotid atherosclerosis measured by high-resolution duplex ultrasound and incident cardiovascular disease.<h4>Results</h4>The C allele was associated not only with prevalent carotid atherosclerosis (odds ratio [OR]: 1.46 [95% confidence interval (CI): 1.13 to 1.88]; OR: 1.43 [95% CI: 1.11 to 1.84]; and OR: 1.44 [95% CI: 1.11 to 1.87] for each copy of C allele, calculated from data collected in 1990, 1995, and 2000, respectively), but also with progression of atherosclerosis (OR: 1.73 [95% CI: 1.36 to 2.21] during 1990 to 1995, and OR: 1.87 [95% CI: 1.44 to 2.42] during 1995 to 2000). In addition, the C allele was related to incident cardiovascular disease (hazard ratio: 1.37 [95% CI: 1.05 to 1.79]). There was evidence of an interaction between genotype and abdominal obesity on atherosclerosis and cardiovascular risk.<h4>Conclusions</h4>The results of this population-based, prospective study indicate that the sequence variation on chromosome 9p21 influences atherosclerosis development and progression.","is_dataset_classified":null,"base_score":5.049856007249537,"endowment":5.049856007249537,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18652946","pmcid":null,"openalex_id":"https://openalex.org/W36880162","authors":[],"funders":[{"funder_name":"British Heart Foundation","grant_id":"","title":null},{"funder_name":"British Heart Foundation","grant_id":"","title":null}],"total_grants":2,"fwci":11.7359,"citation_percentile":0.98791721,"influential_citations":0,"citation_trend":[{"year":2012,"count":15},{"year":2013,"count":13},{"year":2014,"count":6},{"year":2015,"count":8},{"year":2016,"count":13},{"year":2017,"count":11},{"year":2018,"count":7},{"year":2019,"count":4},{"year":2020,"count":4},{"year":2021,"count":2},{"year":2022,"count":7},{"year":2023,"count":2},{"year":2024,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0735109708017051?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0735109708017051?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jacc.2007.11.087","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18652946","host_type":"repository"},{"url":"https://kclpure.kcl.ac.uk/portal/en/publications/eb85fd4d-8558-4c58-9f2a-86bfac16645e","host_type":"repository"}],"fields_of_study":["Genetic Associations and Epidemiology","Genomic variations and chromosomal abnormalities","Kruppel-like factors research","Adult","Aged","Atherosclerosis","Cardiovascular Diseases","Carotid Artery Diseases","Carotid Artery, Common","Chromosomes, Human, Pair 9","Disease Progression","Female","Genetic Predisposition to Disease","Genotype","Humans","Male","Middle Aged","Polymorphism, Single Nucleotide","Prospective Studies","Regression Analysis","Ultrasonography, Doppler, Duplex"],"mesh_terms":["Adult","Aged","Cardiovascular Diseases","Carotid Artery Diseases","Chromosomes, Human, Pair 9","Female","Genotype","Humans","Male","Middle Aged","Prospective Studies","Regression Analysis","Carotid Artery, Common","Disease Progression","Ultrasonography, Doppler, Duplex","Genetic Predisposition to Disease","Polymorphism, Single Nucleotide","Atherosclerosis"],"keywords":["Medicine","Odds ratio","Internal medicine","Hazard ratio","Prospective cohort study","Coronary artery disease","Genotype","Population","Allele","Risk factor","Coronary atherosclerosis","Confidence interval","Genetics","Cardiology","Oncology","Biology","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"refsnp"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-01T21:08:18.028543Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}