{"doi":"10.1016/j.jacbts.2025.101389","title":"Estrogen Influences Human Microvascular Endothelial Function Via Sex-Specific Regulation of Sphingolipids","abstract":"Microvascular endothelial dysfunction strongly predicts poor cardiovascular outcomes, and recent studies have indicated that chronic estrogen treatment promotes endothelial dysfunction in isolated human microvessels. Here, using a translational approach, we demonstrate that sphingolipids are a critical component of estrogen signaling within the human microvascular endothelium. We provide evidence that the stark differences in how estrogen influences the microvascular endothelium are both time- and sex-dependent. This work adds mechanistic insight regarding the complexity and often contradictory relationship between estrogen and cardiovascular risk in humans.","journal":"JACC Basic to Translational Science","year":2025,"id":527314,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9517,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1256323,"name":"Zachary Zirgibel","orcid":"0009-0004-3375-6389","position":1,"is_corresponding":false},{"id":1403993,"name":"Maria Jose Jaramillo-Torres","orcid":"0009-0008-2033-0273","position":2,"is_corresponding":false},{"id":1110073,"name":"Rachel Limpert","orcid":"0009-0000-4899-9720","position":3,"is_corresponding":false},{"id":429092,"name":"Katie E. Cohen","orcid":null,"position":4,"is_corresponding":false},{"id":1404619,"name":"Carolyn Shult","orcid":null,"position":5,"is_corresponding":false},{"id":1403994,"name":"Brian Lindemer","orcid":"0000-0002-5520-4268","position":6,"is_corresponding":false},{"id":1404620,"name":"Henry Bordas-Murphy","orcid":null,"position":7,"is_corresponding":false},{"id":488086,"name":"Callisia N. Clarke","orcid":"0000-0002-5229-961X","position":8,"is_corresponding":false},{"id":427756,"name":"Julie K. Freed","orcid":"0000-0002-9367-2281","position":9,"is_corresponding":false},{"id":322945,"name":"Gopika SenthilKumar","orcid":"0000-0001-5781-1056","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-19T02:50:39.280101Z","pmid":"41139325","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}