{"doi":"10.1016/j.jacbts.2024.11.009","title":"Shear-Thinning Hydrogel for Delayed Delivery of a Small Molecule Metalloproteinase Inhibitor Attenuates Myocardial Infarction Remodeling","abstract":"Strategic delivery of hydrogels to the newly formed myocardial infarction (MI) is an area of active investigation and offers high target specificity for releasing a small molecule therapeutic payload. This study examined the effects of delayed post-MI delivery (pigs, 3 days post-MI) of a shear-thinning hydrogel which encapsulated and released a small molecule matrix metalloproteinase inhibitor. The results demonstrated the feasibility and efficacy of targeted delivery of a shear-thinning injectable hydrogel containing a small molecule matrix metalloproteinase inhibitor to attenuate post-MI remodeling.","journal":"JACC Basic to Translational Science","year":2025,"id":520442,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9546,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":487356,"name":"William M. Torres","orcid":null,"position":1,"is_corresponding":false},{"id":452411,"name":"Lisa Freeburg","orcid":null,"position":2,"is_corresponding":false},{"id":487357,"name":"Shayne C. Barlow","orcid":null,"position":3,"is_corresponding":false},{"id":1390377,"name":"A. Whalen","orcid":null,"position":4,"is_corresponding":false},{"id":321181,"name":"Chima V. Maduka","orcid":"0000-0002-3290-8852","position":5,"is_corresponding":false},{"id":447770,"name":"Tarek Shazly","orcid":"0000-0001-6214-5887","position":6,"is_corresponding":false},{"id":235269,"name":"Jason A. Burdick","orcid":"0000-0002-2006-332X","position":7,"is_corresponding":false},{"id":451813,"name":"Francis G. Spinale","orcid":"0000-0003-0529-5605","position":8,"is_corresponding":false},{"id":1390376,"name":"Joshua E. Mealy","orcid":null,"position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:49:28.470782Z","pmid":"40306854","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}