{"doi":"10.1016/j.jacbts.2024.07.009","title":"Exercise Therapy Rescues Skeletal Muscle Dysfunction and Exercise Intolerance in Cardiometabolic HFpEF","abstract":"Exercise intolerance, a hallmark of heart failure with preserved ejection fraction (HFpEF) exacerbated by obesity, involves unclear mechanisms related to skeletal muscle metabolism. In a \"2-hit\" model of HFpEF, we investigated the ability of exercise therapy (voluntary wheel running) to reverse skeletal muscle dysfunction and exercise intolerance. Using state-of-the-art metabolic cages and a multiomic approach, we demonstrate exercise can rescue dysfunctional skeletal muscle lipid and branched-chain amino acid oxidation and restore exercise capacity in mice with cardiometabolic HFpEF. These results underscore the importance of skeletal muscle metabolism to improve exercise intolerance in HFpEF.","journal":"JACC Basic to Translational Science","year":2024,"id":427073,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9559,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":289078,"name":"Robert C. Noland","orcid":"0000-0001-5543-3450","position":1,"is_corresponding":false},{"id":515497,"name":"James Stampley","orcid":null,"position":2,"is_corresponding":false},{"id":1227103,"name":"Gregory K. Davis","orcid":"0000-0003-1856-3058","position":3,"is_corresponding":false},{"id":465029,"name":"Zhen Li","orcid":"0000-0002-0729-2910","position":4,"is_corresponding":false},{"id":707518,"name":"Eunhan Cho","orcid":"0000-0002-5002-2932","position":5,"is_corresponding":false},{"id":1227104,"name":"Youyoung Kim","orcid":"0009-0005-8099-2445","position":6,"is_corresponding":false},{"id":692493,"name":"Jake E. Doiron","orcid":"0000-0002-4584-4819","position":7,"is_corresponding":false},{"id":456594,"name":"Guillaume Spielmann","orcid":"0000-0001-7024-0972","position":8,"is_corresponding":false},{"id":837106,"name":"Sujoy Ghosh","orcid":"0000-0001-5397-961X","position":9,"is_corresponding":false},{"id":235994,"name":"Sanjiv J. Shah","orcid":"0000-0002-5655-8201","position":10,"is_corresponding":false},{"id":514654,"name":"Brian A. Irving","orcid":"0000-0002-4131-9523","position":11,"is_corresponding":false},{"id":465033,"name":"David J. Lefer","orcid":"0000-0003-2293-7278","position":12,"is_corresponding":false},{"id":514652,"name":"Timothy D. Allerton","orcid":"0000-0001-6364-5787","position":13,"is_corresponding":false},{"id":1218313,"name":"Heather Quiriarte","orcid":"0000-0001-6860-0828","position":0,"is_corresponding":true}],"reference_count":95,"raw_metadata":null,"created_at":"2026-07-19T01:58:47.805440Z","pmid":"39822600","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}