{"doi":"10.1016/j.jacbts.2023.08.011","title":"MANP in Hypertension With Metabolic Syndrome","abstract":"Hypertension and metabolic syndrome frequently coexist to increase the risk for adverse cardiometabolic outcomes. To date, no drug has been proven to be effective in treating hypertension with metabolic syndrome. M-atrial natriuretic peptide is a novel atrial natriuretic peptide analog that activates the particulate guanylyl cyclase A receptor. This study conducted a double-blind, placebo-controlled trial in 22 patients and demonstrated that a single subcutaneous injection of M-atrial natriuretic peptide was safe, well-tolerated, and exerted pleiotropic properties including blood pressure-lowering, lipolytic, and insulin resistance-improving effects. (MANP in Hypertension and Metabolic Syndrome [MANP-HTN-MS]; NCT03781739).","journal":"JACC Basic to Translational Science","year":2023,"id":348648,"datarank":0.5275603700147411,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.15482437254654097,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.15482437254654097,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":11,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.957,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03781739"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":654744,"name":"Paul M. McKie","orcid":"0000-0003-0019-4768","position":1,"is_corresponding":false},{"id":293266,"name":"Seethalakshmi Iyer","orcid":null,"position":2,"is_corresponding":false},{"id":1091281,"name":"Christopher Scott","orcid":"0000-0002-2630-6177","position":3,"is_corresponding":false},{"id":228990,"name":"Kent R. Bailey","orcid":"0000-0001-8968-643X","position":4,"is_corresponding":false},{"id":972766,"name":"Bradley K. Johnson","orcid":"0000-0002-9005-3434","position":5,"is_corresponding":false},{"id":1091865,"name":"Sherry L. Benike","orcid":null,"position":6,"is_corresponding":false},{"id":413598,"name":"Horng H. Chen","orcid":"0000-0002-2315-0330","position":7,"is_corresponding":false},{"id":348592,"name":"Wayne L. Miller","orcid":"0000-0002-0863-9509","position":8,"is_corresponding":false},{"id":1091282,"name":"Aderville Cabassi","orcid":"0000-0001-8262-5669","position":9,"is_corresponding":false},{"id":290758,"name":"John C. Burnett","orcid":"0000-0002-3414-1659","position":10,"is_corresponding":false},{"id":706588,"name":"Valentina Cannone","orcid":"0000-0002-5168-8381","position":11,"is_corresponding":false},{"id":672837,"name":"Xiao Ma","orcid":"0000-0001-9940-8468","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T01:12:10.335697Z","pmid":"38362338","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}