{"doi":"10.1016/j.jacbts.2022.04.007","title":"Acute Glycogen Synthase Kinase-3 Inhibition Modulates Human Cardiac Conduction","abstract":"Glycogen synthase kinase 3 (GSK-3) inhibition has emerged as a potential therapeutic target for several diseases, including cancer. However, the role for GSK-3 regulation of human cardiac electrophysiology remains ill-defined. We demonstrate that SB216763, a GSK-3 inhibitor, can acutely reduce conduction velocity in human cardiac slices. Combined computational modeling and experimental approaches provided mechanistic insight into GSK-3 inhibition-mediated changes, revealing that decreased sodium-channel conductance and tissue conductivity may underlie the observed phenotypes. Our study demonstrates that GSK-3 inhibition in human myocardium alters electrophysiology and may predispose to an arrhythmogenic substrate; therefore, monitoring for adverse arrhythmogenic events could be considered.","journal":"JACC Basic to Translational Science","year":2022,"id":269765,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9544,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":933000,"name":"Brittany D. Brumback","orcid":"0000-0002-8376-4959","position":1,"is_corresponding":false},{"id":590580,"name":"Lei Huang","orcid":"0000-0002-0568-0645","position":2,"is_corresponding":false},{"id":628387,"name":"David M. Zhang","orcid":"0000-0002-4054-3312","position":3,"is_corresponding":false},{"id":629456,"name":"Tiankai Yin","orcid":null,"position":4,"is_corresponding":false},{"id":582708,"name":"Catherine E. Lipovsky","orcid":"0000-0001-9639-366X","position":5,"is_corresponding":false},{"id":1437,"name":"Stephanie C. Hicks","orcid":"0000-0002-7858-0231","position":6,"is_corresponding":false},{"id":933001,"name":"Jesús Jiménez","orcid":"0000-0001-5399-8538","position":7,"is_corresponding":false},{"id":498942,"name":"Patrick M. Boyle","orcid":"0000-0001-9048-1239","position":8,"is_corresponding":false},{"id":628396,"name":"Stacey Rentschler","orcid":"0000-0002-1744-1238","position":9,"is_corresponding":false},{"id":628393,"name":"Gang Li","orcid":"0000-0001-9661-8304","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-19T00:27:22.602796Z","pmid":"36337924","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}