{"doi":"10.1016/j.jacbts.2022.02.008","title":"Cardiac Spinal Afferent Denervation Attenuates Renal Dysfunction in Rats With Cardiorenal Syndrome Type 2","abstract":"Cardiorenal syndrome type 2 (CRS2) is defined as a chronic cardiovascular disease, usually chronic heart failure (CHF), resulting in chronic kidney disease. We hypothesized that the cardiac spinal afferent reflex (CSAR) plays a critical role in the development of CRS2. Our data suggest that cardiac afferent ablation by resiniferatoxin not only improves cardiac function but also benefits the kidneys and increases long-term survival in the myocardial infarction model of CHF. We also found that renal denervation has a similar reno-protective effect in CHF rats. We believe this novel work contributes to the development of a unique neuromodulation therapy to treat CHF patients.","journal":"JACC Basic to Translational Science","year":2022,"id":261046,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9601,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":320559,"name":"Neetha Nanoth Vellichirammal","orcid":"0000-0002-5740-7093","position":1,"is_corresponding":false},{"id":227649,"name":"Han Li","orcid":"0000-0002-1988-8279","position":2,"is_corresponding":false},{"id":284729,"name":"Lie Gao","orcid":"0000-0002-7880-7213","position":3,"is_corresponding":false},{"id":856197,"name":"Erika I. Boesen","orcid":"0000-0002-5672-9197","position":4,"is_corresponding":false},{"id":827616,"name":"Alicia M. Schiller","orcid":"0000-0002-0899-7584","position":5,"is_corresponding":false},{"id":827615,"name":"Peter Ricci Pellegrino","orcid":"0000-0001-7880-7072","position":6,"is_corresponding":false},{"id":489247,"name":"Steven J. Lisco","orcid":"0000-0003-4307-9807","position":7,"is_corresponding":false},{"id":66211,"name":"Chittibabu Guda","orcid":"0000-0002-5393-9316","position":8,"is_corresponding":false},{"id":284731,"name":"Irving H. Zucker","orcid":"0000-0003-3636-7720","position":9,"is_corresponding":false},{"id":320565,"name":"Hanjun Wang","orcid":"0000-0001-5906-8980","position":10,"is_corresponding":false},{"id":720532,"name":"Zhiqiu Xia","orcid":"0000-0002-1430-8992","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-19T00:26:12.158801Z","pmid":"35818505","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}