{"doi":"10.1016/j.jacbts.2022.01.013","title":"Plasma Proteomics of COVID-19–Associated Cardiovascular Complications","abstract":"To gain insights into the mechanisms driving cardiovascular complications in COVID-19, we performed a case-control plasma proteomics study in COVID-19 patients. Our results identify the senescence-associated secretory phenotype, a marker of biological aging, as the dominant process associated with disease severity and cardiac involvement. FSTL3, an indicator of senescence-promoting Activin/TGFβ signaling, and ADAMTS13, the von Willebrand Factor-cleaving protease whose loss-of-function causes microvascular thrombosis, were among the proteins most strongly associated with myocardial stress and injury. Findings were validated in a larger COVID-19 patient cohort and the hamster COVID-19 model, providing new insights into the pathophysiology of COVID-19 cardiovascular complications with therapeutic implications.","journal":"JACC Basic to Translational Science","year":2022,"id":246518,"datarank":0.5495342469194471,"base_score":3.6635616461296463,"endowment":3.6635616461296463,"self_citation_contribution":0.5495342469194471,"citation_network_contribution":0.0,"self_endowment_contribution":0.5495342469194471,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":38,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9594,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":27817,"name":"Robert R. Kitchen","orcid":"0000-0003-1443-8559","position":1,"is_corresponding":false},{"id":481021,"name":"J. Sawalla Guseh","orcid":"0000-0003-0992-5635","position":2,"is_corresponding":false},{"id":457210,"name":"Jenna McNeill","orcid":"0000-0001-7032-4228","position":3,"is_corresponding":false},{"id":242324,"name":"Malika Aïd","orcid":"0000-0002-4498-7893","position":4,"is_corresponding":false},{"id":107591,"name":"Amanda J. Martinot","orcid":"0000-0001-6237-6191","position":5,"is_corresponding":false},{"id":239227,"name":"Andy Yu","orcid":null,"position":6,"is_corresponding":false},{"id":296693,"name":"Colin Platt","orcid":null,"position":7,"is_corresponding":false},{"id":669095,"name":"James Rhee","orcid":"0000-0002-2181-4957","position":8,"is_corresponding":false},{"id":301185,"name":"Brittany Weber","orcid":"0000-0002-0177-2091","position":9,"is_corresponding":false},{"id":807497,"name":"Lena Trager","orcid":null,"position":10,"is_corresponding":false},{"id":426022,"name":"Margaret H. Hastings","orcid":"0000-0001-9333-5210","position":11,"is_corresponding":false},{"id":107596,"name":"Sarah Ducat","orcid":"0000-0002-5285-7642","position":12,"is_corresponding":false},{"id":806936,"name":"Peng Xia","orcid":"0000-0003-3891-3385","position":13,"is_corresponding":false},{"id":806937,"name":"Claire Castro","orcid":"0000-0002-6309-1689","position":14,"is_corresponding":false},{"id":843681,"name":"Abhilasha Singh","orcid":"0000-0003-2274-0862","position":15,"is_corresponding":false},{"id":807498,"name":"Bjarni Atlason","orcid":null,"position":16,"is_corresponding":false},{"id":316988,"name":"Timothy W. Churchill","orcid":"0000-0002-0215-3049","position":17,"is_corresponding":false},{"id":260674,"name":"Marcelo F. Di Carli","orcid":"0000-0003-3119-025X","position":18,"is_corresponding":false},{"id":896,"name":"Patrick T. Ellinor","orcid":"0000-0002-2067-0533","position":19,"is_corresponding":false},{"id":106527,"name":"Dan H. Barouch","orcid":"0000-0001-5127-4659","position":20,"is_corresponding":false},{"id":892,"name":"Jennifer E. Ho","orcid":"0000-0002-7987-4768","position":21,"is_corresponding":false},{"id":294916,"name":"Anthony Rosenzweig","orcid":"0000-0001-6387-0386","position":22,"is_corresponding":false},{"id":294908,"name":"Jason D. Roh","orcid":"0000-0002-6999-6868","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:23:48.622830Z","pmid":"35530264","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}