{"doi":"10.1016/j.jacbts.2020.11.012","title":"Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities","abstract":"A lack of preclinical large animal models of heart failure with preserved ejection fraction (HFpEF) that recapitulate this comorbid-laden syndrome has led to the inability to tease out mechanistic insights and to test novel therapeutic strategies. This study developed a large animal model that integrated multiple comorbid determinants of HFpEF in a miniswine breed that exhibited sensitivity to obesity, metabolic syndrome, and vascular disease with overt clinical signs of heart failure. The combination of a Western diet and 11-deoxycorticosterone acetate salt-induced hypertension in the Göttingen miniswine led to the development of a novel large animal model of HFpEF that exhibited multiorgan involvement and a full spectrum of comorbidities associated with human HFpEF.","journal":"JACC Basic to Translational Science","year":2021,"id":162300,"datarank":0.586803450814222,"base_score":3.912023005428146,"endowment":3.912023005428146,"self_citation_contribution":0.586803450814222,"citation_network_contribution":0.0,"self_endowment_contribution":0.586803450814222,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":49,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9087,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":503106,"name":"Amy Scarborough","orcid":"0000-0002-8275-891X","position":1,"is_corresponding":false},{"id":465029,"name":"Zhen Li","orcid":"0000-0002-0729-2910","position":2,"is_corresponding":false},{"id":466343,"name":"David J. Polhemus","orcid":null,"position":3,"is_corresponding":false},{"id":679521,"name":"Hunter A. Hidalgo","orcid":null,"position":4,"is_corresponding":false},{"id":679522,"name":"Jeffery D. Schumacher","orcid":null,"position":5,"is_corresponding":false},{"id":261149,"name":"Timothy Matsuura","orcid":null,"position":6,"is_corresponding":false},{"id":678830,"name":"J. Stephen Jenkins","orcid":"0000-0001-8446-5208","position":7,"is_corresponding":false},{"id":258826,"name":"Daniel P. Kelly","orcid":"0000-0002-3811-9491","position":8,"is_corresponding":false},{"id":503991,"name":"Traci Goodchild","orcid":null,"position":9,"is_corresponding":false},{"id":465033,"name":"David J. Lefer","orcid":"0000-0003-2293-7278","position":10,"is_corresponding":false},{"id":465030,"name":"Thomas E. Sharp","orcid":"0000-0001-8706-9825","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:45:00.600065Z","pmid":"33665515","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}