{"doi":"10.1016/j.jacadv.2025.102363","title":"Enhancing Prediction of Cancer Therapy-Related Cardiomyopathy From Surveillance Echocardiograms","abstract":"BACKGROUND: Early echocardiographic indicators of cardiac remodeling may enhance cardiomyopathy risk prediction in childhood cancer survivors (CCS). OBJECTIVES: The objective of the study was to assess whether influential echocardiographic measures can be combined to develop a robust cardiomyopathy risk prediction model in CCS. METHODS: Multicenter retrospective study of ≥1-year CCS with digitally archived surveillance echocardiograms, enrolled cardiomyopathy cases (left ventricular [LV] fractional shortening ≤28% or LV ejection fraction ≤50% on ≥2 occasions) and noncases (≥5-year CCS who maintained fractional shortening ≥ 30% and ejection fraction ≥55% without initiation of cardiac medications). Echocardiograms were centrally quantitated in a blinded fashion. Least absolute shrinkage and selection operator regression identified the most influential 2-year predictors of cardiomyopathy among 27 echocardiographic parameters. Logistic regression was used to generate ORs with 95% CIs. Estimates were applied to the training and test data sets to generate area under the receiver operating characteristic curves (AUC). RESULTS: : 1.3; 95% CI: 1.1-1.6) were strongly predictive of cardiomyopathy. AUCs were similar if cancer treatment exposures were included. CONCLUSIONS: Early abnormalities in echocardiographic parameters of structure and function predict subsequent cardiomyopathy in CCS and can identify high-risk survivors who warrant early intervention.","journal":"JACC Advances","year":2025,"id":582921,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.945,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":230925,"name":"Kayla Stratton","orcid":"0000-0002-5201-4565","position":1,"is_corresponding":false},{"id":746376,"name":"Ritu Sachdeva","orcid":"0000-0001-5080-7433","position":2,"is_corresponding":false},{"id":401865,"name":"Saro H. Armenian","orcid":"0000-0003-2604-8603","position":3,"is_corresponding":false},{"id":734835,"name":"Aarti Bhat","orcid":"0000-0002-6214-489X","position":4,"is_corresponding":false},{"id":498942,"name":"Patrick M. Boyle","orcid":"0000-0001-9048-1239","position":5,"is_corresponding":false},{"id":1175760,"name":"Lindsay A. Edwards","orcid":"0000-0003-0555-0127","position":6,"is_corresponding":false},{"id":781573,"name":"Lillian R. Meacham","orcid":"0000-0003-4394-0070","position":7,"is_corresponding":false},{"id":412325,"name":"Shanti Narasimhan","orcid":"0000-0001-9065-3651","position":8,"is_corresponding":false},{"id":85413,"name":"Paul C. Nathan","orcid":"0000-0003-0334-0871","position":9,"is_corresponding":false},{"id":415919,"name":"Karim Thomas Sadak","orcid":"0000-0002-4511-5456","position":10,"is_corresponding":false},{"id":1397712,"name":"Surbhi Sharma","orcid":"0000-0001-9288-2685","position":11,"is_corresponding":false},{"id":782126,"name":"William L. Border","orcid":null,"position":12,"is_corresponding":false},{"id":230926,"name":"Wendy M. Leisenring","orcid":"0000-0001-7405-0906","position":13,"is_corresponding":false},{"id":254221,"name":"Eric J. Chow","orcid":"0000-0003-3349-9330","position":14,"is_corresponding":false},{"id":737554,"name":"Kasey J. Leger","orcid":"0000-0002-7905-6714","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:58:59.653747Z","pmid":"41273917","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}