{"doi":"10.1016/j.jacadv.2025.101625","title":"Does Adiponectin Inform Cardiovascular Risk in Older Adults?","abstract":"BACKGROUND: Adiponectin, an atheroprotective adipokine, is associated with adverse outcomes in older age. It is unclear whether this is due to overlapping pathophysiological pathways with N-terminal pro-B-type natriuretic peptide (NT-proBNP). OBJECTIVES: The authors investigated adiponectin's associations with cardiovascular disease (CVD) risk in older adults. METHODS: Among Atherosclerosis Risk in Communities prospective cohort study participants without baseline CVD at visit 5 (n = 4,729, mean age 75), adiponectin and adiponectin/NT-proBNP category associations with incident CVD events (heart failure [HF], atherosclerotic cardiovascular disease, and death during median follow-up of 5.5 years) and echocardiographic parameters were assessed. Metabolomic signatures of adiponectin/NT-proBNP categories were explored. RESULTS: Higher adiponectin was associated with older age, female sex, and less obesity, diabetes, and hypertension but increased risk for incident HF (HR: 1.91 [95% CI: 1.49-2.44], per natural-log unit increase) and CVD death (HR: 1.67 [95% CI: 1.19-2.32]). Interaction of NT-proBNP with adiponectin was significant for HF (P-interaction = 0.03). There was no significant association between adiponectin and heart failure with preserved ejection fraction after adjusting for NT-proBNP. Elevations of both biomarkers (A+ [upper tertile]/N+ [≥125 pg/mL]) had higher risk (vs A+/N-; HF: HR 5.41 [95% CI: 2.72-10.78]; CVD death: HR 3.50 [95% CI: 1.48-8.24]). Compared with A+/N-, A-/N+ had increased risk for HF (HR 2.84 [95% CI: 1.41-5.72]) while A-/N- had no increased event risk. A+/N+'s metabolomic signature (88% similar to NT-proBNP's) showed acylcarnitine species consistent with incomplete beta-oxidation; top-associated metabolites were significantly associated with HF and CVD death. CONCLUSIONS: Elevated adiponectin and NT-proBNP in older adults are associated with increased risk for HF and CVD death beyond traditional risk factors.","journal":"JACC Advances","year":2025,"id":540417,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8966,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":331913,"name":"Xiaoming Jia","orcid":"0000-0001-7949-6173","position":1,"is_corresponding":false},{"id":1115217,"name":"Xu Lu","orcid":"0000-0003-4892-5240","position":2,"is_corresponding":false},{"id":363,"name":"Chao Cheng","orcid":"0000-0002-5002-3417","position":3,"is_corresponding":false},{"id":340495,"name":"Chiadi E. Ndumele","orcid":"0000-0002-1603-282X","position":4,"is_corresponding":false},{"id":331914,"name":"Caroline Sun","orcid":"0000-0002-3192-0067","position":5,"is_corresponding":false},{"id":331917,"name":"B. Gwen Windham","orcid":"0000-0001-6240-5044","position":6,"is_corresponding":false},{"id":22652,"name":"Kunihiro Matsushita","orcid":"0000-0002-7179-718X","position":7,"is_corresponding":false},{"id":1337056,"name":"Bing Yu","orcid":"0000-0002-6431-184X","position":8,"is_corresponding":false},{"id":326870,"name":"Vijay Nambi","orcid":"0000-0002-4237-0267","position":9,"is_corresponding":false},{"id":97055,"name":"Biykem Bozkurt","orcid":"0000-0002-6362-0253","position":10,"is_corresponding":false},{"id":276837,"name":"Jane E.B. Reusch","orcid":"0000-0001-8620-1003","position":11,"is_corresponding":false},{"id":261908,"name":"Casey M. Rebholz","orcid":"0000-0002-5442-8745","position":12,"is_corresponding":false},{"id":405218,"name":"Elizabeth Selvin","orcid":"0000-0002-3539-2070","position":13,"is_corresponding":false},{"id":233725,"name":"Christie M. Ballantyne","orcid":"0000-0002-6432-1730","position":14,"is_corresponding":false},{"id":233724,"name":"Ron C. Hoogeveen","orcid":"0000-0003-2399-4653","position":15,"is_corresponding":false},{"id":867523,"name":"Layla A. Abushamat","orcid":"0000-0002-4074-881X","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:52:38.861025Z","pmid":"39983616","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}