{"doi":"10.1016/j.jacadv.2024.101543","title":"Sex Differences in the Safety and Efficacy of Different Durations of DAPT After PCI","abstract":"Background: Randomized controlled trials (RCTs) have examined the clinical impact of abbreviating the duration of dual antiplatelet therapy (DAPT) and have reported outcomes in men and women. Objectives: The authors examined the safety and efficacy of different durations of DAPT following percutaneous coronary intervention (PCI) in men and women. Methods: We searched Cochrane, Embase, MEDLINE, PubMed, Scopus, and Web of Science databases for RCTs that compared any 2 of 1, 3, 6, or 12 months of DAPT after PCI and reported outcomes in men and women. We performed a systematic review and network meta-analysis to examine sex-based differences in net adverse clinical events (NACE), major adverse cardiovascular events (MACE), and bleeding. Results: Fifteen RCTs were included, comprising 44,610 men (74.7%) and 15,132 women (25.3%). No difference in NACE or MACE was observed between 1, 3, 6, or 12 months of DAPT in both sexes. In both men and women, 1 and 3 months of DAPT were each associated with lower risk of bleeding compared with 12 months of DAPT. In women, 3 months of DAPT was associated with a lower risk of bleeding compared with 6 months. Similar results were found in sensitivity analysis of acute coronary syndrome-only trials. Conclusions: No significant sex-based differences in NACE or MACE were observed with different durations of DAPT after PCI, while a lower bleeding risk was observed with shorter DAPT (1-3 months) among both sexes. This suggests that shorter DAPT may be preferred in both sexes following PCI, especially in those with high bleeding risk.","journal":"JACC Advances","year":2025,"id":522524,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9551,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":103993,"name":"Shiwani Mahajan","orcid":"0000-0002-5617-489X","position":1,"is_corresponding":false},{"id":1123304,"name":"Emily Fishman","orcid":"0000-0001-6999-5841","position":2,"is_corresponding":false},{"id":1123305,"name":"Alexander Ambrosini","orcid":"0009-0003-5399-2322","position":3,"is_corresponding":false},{"id":1394049,"name":"Laura Marcela Romero Acero","orcid":"0000-0002-9851-5509","position":4,"is_corresponding":false},{"id":291340,"name":"Jiun‐Ruey Hu","orcid":"0000-0003-1390-508X","position":5,"is_corresponding":false},{"id":1256042,"name":"Greta Campbell","orcid":null,"position":6,"is_corresponding":false},{"id":1255657,"name":"Golsa Babapour","orcid":"0009-0009-5018-3099","position":7,"is_corresponding":false},{"id":706689,"name":"Michelle D. Kelsey","orcid":"0000-0002-2169-043X","position":8,"is_corresponding":false},{"id":282488,"name":"Pamela S. Douglas","orcid":"0000-0001-9876-4049","position":9,"is_corresponding":false},{"id":103989,"name":"Aakriti Gupta","orcid":"0000-0001-9103-9872","position":10,"is_corresponding":false},{"id":1032349,"name":"Jennifer Frampton","orcid":"0000-0001-5141-7920","position":11,"is_corresponding":false},{"id":441473,"name":"Michael G. Nanna","orcid":"0000-0002-5487-4542","position":12,"is_corresponding":false},{"id":940023,"name":"Dae Yong Park","orcid":"0000-0002-1486-7452","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:49:54.058858Z","pmid":"39886301","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}