{"doi":"10.1016/j.jacadv.2024.101426","title":"Long-Term Impact of Pregnancy on Clinical Outcomes in Individuals With Hypertrophic Cardiomyopathy","abstract":"Background: The effect of pregnancy on individuals with hypertrophic cardiomyopathy (HCM) is not well investigated. Objectives: The purpose of this study was to assess the impact of pregnancy on all-cause mortality and clinical outcomes among individuals with HCM. Methods: Using the TriNetX research network, we identified individuals within reproductive age (≥18-45 years) with a diagnosis of HCM between 2012 and 2022 (n = 10,936). Patients were stratified based on pregnancy history into 2 groups: 1) those with a history of pregnancy/high-risk pregnancy supervision; and 2) those without a history of pregnancy or subsequent antenatal/pregnancy supervision encounters throughout the study period. Propensity score matching resulted in 3,399 patients in each cohort. The primary outcome was all-cause mortality. Secondary outcomes include a composite of arrhythmic events (defined as sudden cardiac death, appropriate shocks, sustained ventricular tachycardia/ventricular fibrillation), major adverse cardiovascular events (MACE), and acute heart failure exacerbation during 10 years of follow-up. Results: = 0.55) between both groups. In subgroup analysis of obstructive HCM, the findings were similar between both pregnancy and no pregnancy groups. Conclusions: Pregnancy in individuals with HCM was not associated with a higher risk of adverse outcomes at long-term follow-up. Further efforts are warranted to better understand the short-term outcomes in this high-risk population.","journal":"JACC Advances","year":2024,"id":447864,"datarank":0.36664066794931316,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.05472443669733774,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.05472443669733774,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":6,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6268,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":767931,"name":"Omar Abdelfattah","orcid":"0000-0001-8025-9212","position":1,"is_corresponding":false},{"id":1266486,"name":"Omar Chaabo","orcid":null,"position":2,"is_corresponding":false},{"id":1069249,"name":"Danielle El Haddad","orcid":null,"position":3,"is_corresponding":false},{"id":1265999,"name":"Garima Sharma","orcid":"0000-0003-0117-6000","position":4,"is_corresponding":false},{"id":1266487,"name":"Amy M. Ahnert","orcid":null,"position":5,"is_corresponding":false},{"id":940792,"name":"Matthew W. Martinez","orcid":null,"position":6,"is_corresponding":false},{"id":505950,"name":"Baha M. Sibai","orcid":"0000-0001-9982-7873","position":7,"is_corresponding":false},{"id":851636,"name":"Wissam Khalife","orcid":"0000-0002-2234-3552","position":8,"is_corresponding":false},{"id":1266485,"name":"Jasmin Abdeldayem","orcid":null,"position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:02:03.354708Z","pmid":"39811753","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}