{"doi":"10.1016/j.jacadv.2023.100265","title":"Prevalence and Correlates of Elevated NT-proBNP in Pregnant Women in the General U.S. Population","abstract":"BACKGROUND: Physiologic changes in N-terminal pro-B-type natriuretic peptide (NT-proBNP) across trimesters of pregnancy have not been well studied. OBJECTIVES: The authors aimed to measure NT-proBNP in adult women, by pregnancy status and trimester, in a nationally representative sample from the National Health and Nutrition Examination Survey 1999 to 2004. METHODS: We conducted a cross-sectional analysis of 2,134 women (546 pregnant) aged 20 to 40 years without a history of cardiovascular disease. RESULTS: Among pregnant women in the first trimester, the prevalence of elevated NT-proBNP (>125 pg/mL) was 20.0% (SE, 6.6%) compared to 2.4% (SE, 0.8%) among women in the third trimester and 8.0% among nonpregnant women. After adjustment for demographics and cardiovascular risk factors, NT-proBNP was 44% higher (absolute difference 26.4 [95% CI: 11.2-41.6] pg/mL) in the first trimester of pregnancy compared to nonpregnant women. Among pregnant women only, adjusted NT-proBNP was 46% lower (absolute difference -22.2 [95% CI: -36.9 to -7.5] pg/mL) in women in the third trimester compared to women in the first trimester. NT-proBNP was inversely associated with body mass index and with systolic blood pressure. CONCLUSIONS: Women in the first trimester of pregnancy had significantly higher NT-proBNP than those in the third trimester and compared to similarly aged nonpregnant women. The dynamic nature of NT-proBNP should be taken into consideration when ordering NT-proBNP lab tests in pregnant women.","journal":"JACC Advances","year":2023,"id":326453,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7387,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":441182,"name":"Mary R. Rooney","orcid":"0000-0002-5607-4848","position":1,"is_corresponding":false},{"id":320584,"name":"Michael Fang","orcid":"0000-0003-2849-1780","position":2,"is_corresponding":false},{"id":429762,"name":"Sui Zhang","orcid":"0000-0001-8279-6353","position":3,"is_corresponding":false},{"id":340495,"name":"Chiadi E. Ndumele","orcid":"0000-0002-1603-282X","position":4,"is_corresponding":false},{"id":333107,"name":"Olive Tang","orcid":"0000-0002-8075-1298","position":5,"is_corresponding":false},{"id":738553,"name":"Steven P. Schulman","orcid":"0000-0003-3964-8886","position":6,"is_corresponding":false},{"id":236349,"name":"Erin D. Michos","orcid":"0000-0002-5547-5084","position":7,"is_corresponding":false},{"id":340496,"name":"John W. McEvoy","orcid":"0000-0001-6530-5479","position":8,"is_corresponding":false},{"id":377294,"name":"Justin B. Echouffo‐Tcheugui","orcid":"0000-0002-8460-1617","position":9,"is_corresponding":false},{"id":479551,"name":"Robert H. Christenson","orcid":"0000-0003-2612-9083","position":10,"is_corresponding":false},{"id":405218,"name":"Elizabeth Selvin","orcid":"0000-0002-3539-2070","position":11,"is_corresponding":false},{"id":497799,"name":"Anum Minhas","orcid":"0000-0001-6680-0404","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-19T01:08:33.106703Z","pmid":"37168845","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}