{"doi":"10.1016/j.jaad.2025.10.019","title":"Examining the impact of child atopic dermatitis on maternal depression: A longitudinal cohort study","abstract":"BACKGROUND: Longitudinal data on mental health in caregivers of children with atopic dermatitis (AD) are limited. OBJECTIVE: Examine the relationship between child AD activity and severity with maternal depression across childhood. METHODS: Longitudinal cohort study of 12,124 mother-child dyads from the Avon Longitudinal Study of Parents and Children. RESULTS: Mixed linear regression models revealed mothers of children with active AD had higher Edinburgh Postnatal Depression Scale (EPDS) scores, with an average increase of 0.33 points (95% CI, 0.17-0.49) after adjusting for child sex, age, maternal age at delivery, maternal race and ethnicity, measures of socioeconomic status, maternal history of AD, and maternal history of pre- and postnatal depression. Severe AD was associated with a 0.68-point increase in EPDS scores (95% CI, 0.46-0.90) or a 45% increase in the odds of clinically relevant symptoms (OR, 1.45; 95% CI, 1.12-1.87). A dose-response relationship between maternal depression and AD severity was observed throughout childhood, with the largest effect sizes at ages 3 to 7 years among mothers of children with severe AD from lower socioeconomic backgrounds. LIMITATION: Potential reporting bias from participant self-reports. CONCLUSIONS: Child AD was associated with higher maternal depression scores, especially during early childhood for mothers of children from disadvantaged backgrounds with more severe AD.","journal":"Journal of the American Academy of Dermatology","year":2025,"id":527087,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7891,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1403740,"name":"Ahnna Lee","orcid":null,"position":1,"is_corresponding":false},{"id":632598,"name":"Sheng‐Pei Wang","orcid":"0000-0001-8167-5015","position":2,"is_corresponding":false},{"id":645864,"name":"Morgan Ye","orcid":"0000-0002-0023-8946","position":3,"is_corresponding":false},{"id":1016728,"name":"Korey Capozza","orcid":"0000-0003-2201-6655","position":4,"is_corresponding":false},{"id":1403741,"name":"Ashley Wimberly Ellis","orcid":null,"position":5,"is_corresponding":false},{"id":347118,"name":"Angela Fox","orcid":"0000-0003-4031-5747","position":6,"is_corresponding":false},{"id":275838,"name":"Kaja Z. LeWinn","orcid":"0000-0002-8245-7279","position":7,"is_corresponding":false},{"id":588822,"name":"Katrina Abuabara","orcid":"0000-0002-7736-6946","position":8,"is_corresponding":false},{"id":1403739,"name":"Hannah Eunhae Kang","orcid":null,"position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:50:34.851930Z","pmid":"41061988","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}