{"doi":"10.1016/j.jaad.2025.08.044","title":"Effect of prenatal high-dose vitamin D on childhood atopic dermatitis is modified by maternal cotinine metabolome: A secondary analysis of a randomized clinical trial","abstract":null,"journal":"Journal of the American Academy of Dermatology","year":2026,"id":618025,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1152797,"name":"Tingting Wang","orcid":"0000-0001-5288-2314","position":1,"is_corresponding":false},{"id":1484063,"name":"Liang Chen","orcid":"0000-0002-6549-4510","position":2,"is_corresponding":false},{"id":225086,"name":"Hannah Kaiser","orcid":"0000-0002-3991-7401","position":3,"is_corresponding":false},{"id":1594055,"name":"Beatriz Gomes","orcid":null,"position":4,"is_corresponding":false},{"id":1594056,"name":"Amalie Klein","orcid":null,"position":5,"is_corresponding":false},{"id":1594057,"name":"Nilo Vahman","orcid":null,"position":6,"is_corresponding":false},{"id":160470,"name":"Lone Skov","orcid":"0000-0002-4784-9680","position":7,"is_corresponding":false},{"id":241503,"name":"Jakob Stokholm","orcid":"0000-0003-4989-9769","position":8,"is_corresponding":false},{"id":1594058,"name":"Ann-Marie Schoos","orcid":null,"position":9,"is_corresponding":false},{"id":241476,"name":"Klaus Bønnelykke","orcid":"0000-0003-2003-1018","position":10,"is_corresponding":false},{"id":241480,"name":"Bo Chawes","orcid":"0000-0001-6846-6243","position":11,"is_corresponding":false},{"id":657145,"name":"Nicklas Brustad","orcid":"0000-0001-6383-8845","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Effect of prenatal high-dose vitamin D on childhood atopic dermatitis is modified by maternal cotinine metabolome: A secondary analysis of a randomized clinical trial","abstract":"Background Tobacco exposure has been shown to modulate the effect of vitamin D on the risk of atopic diseases. However, randomized clinical trials investigating the potential effect modification between tobacco exposure and vitamin D supplementation on atopic disease risk are lacking. Objective We sought to investigate the potential effect modification from maternal tobacco exposure on the effect of prenatal high-dose vitamin D supplementation on the risk of child atopic dermatitis, asthma, and allergic rhinitis. Methods A post hoc analysis in the double-blinded COPSAC 2010 randomized clinical trial (NCT00856947) including 581 mother–child pairs randomized to 2800 IU/d (high-dose) versus 400 IU/d (standard-dose) from pregnancy week 24. Maternal blood metabolomic profiling was performed at inclusion, reflecting maternal tobacco exposure using a supervised sparse partial least squares model. Results We found a significant effect modification from the maternal cotinine metabolome score ( P interaction < .01) where high-dose vitamin D reduced atopic dermatitis until the age of 6 years in offspring from mothers with highest (fourth quartile) cotinine metabolome score: crude; hazard ratio=0.46 (0.23-0.93), P = .03, and adjusted for sex, birth season, socioeconomic circumstances, living environment, air pollution, maternal diet, vitamin D levels, and fish oil intervention; hazard ratio=0.36 (0.15-0.85), P = .02. Similarly, significant effect modification was demonstrated on the risk of asthma ( P interaction = .03) until the age of 6 years but not allergic rhinitis ( P interaction = .08) at the age of 6 years. Conclusions This exploratory study of prespecified randomized clinical trial outcomes demonstrates effect modifications of the maternal tobacco exposure metabolome on the primary preventive effect of prenatal high-dose vitamin D on offspring atopic disease risk, suggesting a potential personalized prevention strategy targeting mothers exposed to tobacco smoking.","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40865727","pmcid":null,"openalex_id":"https://openalex.org/W4413971466","authors":[],"funders":[{"funder_name":"Horizon 2020 Framework Programme","grant_id":"946228","title":"Dietary shaping of the early life metabolome and its role in healthy lung and brain development"},{"funder_name":"Lundbeckfonden","grant_id":"R381-2021-1428","title":null},{"funder_name":"European Research Council","grant_id":"","title":null}],"total_grants":3,"fwci":3.0373,"citation_percentile":0.91773712,"influential_citations":0,"citation_trend":[{"year":2025,"count":1},{"year":2026,"count":3}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.jaad.2025.08.044","host_type":"journal"},{"url":"https://doi.org/10.1016/j.jaad.2025.08.044","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0190962225026702?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0190962225026702?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40865727","host_type":"repository"},{"url":"https://researchprofiles.ku.dk/da/publications/c6dfc6b7-f296-478e-a79c-9c3c31c11e52","host_type":"repository"},{"url":"https://curis.ku.dk/ws/files/530849914/1-s2.0-S0190962225026702-main.pdf","host_type":"repository"}],"fields_of_study":["Vitamin D Research Studies","Dermatology and Skin Diseases","Gut microbiota and health","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":["Adult","Asthma","Child","Child, Preschool","Cotinine","Dermatitis, Atopic","Double-Blind Method","Female","Humans","Infant","Male","Pregnancy","Prenatal Exposure Delayed Effects","Vitamin D","Dietary Supplements","Metabolome","Rhinitis, Allergic"],"keywords":["Medicine","Cotinine","Atopic dermatitis","Metabolome","Randomized controlled trial","Vitamin","Dermatology","Internal medicine","Nicotine","Metabolite","Environment","Vitamin D","Metabolomics","Primary Prevention","Tobacco Exposure","Male","Adult","Infant","Rhinitis, Allergic","Asthma","Dermatitis, Atopic","Double-Blind Method","Pregnancy","Prenatal Exposure Delayed Effects","Child, Preschool","Dietary Supplements","Humans","Female","Child"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T03:14:05.961876Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}