{"doi":"10.1016/j.jaad.2025.02.015","title":"Patients with PSOriasis and Suppurative Hidradenitis (PSO-SH) share genetic risk factors and are at risk of increased morbidity","abstract":"BACKGROUND: Select patients are diagnosed with both psoriasis (PSO) and hidradenitis suppurativa (HS), leading to a unique disease pattern. Genetic risk factors remain unidentified. METHODS: The study harnessed an international collection of patients with PSO and HS (PSO-SH). Clinical and genetic data were collected and analyzed. RESULTS: Eighty-seven PSO-SH patients (70% female) were identified. They had a high number of comorbidities (89%) and worse general physical health compared to PSO-only (OR: 3.09; 95% CI: 1.56-6.12) or HS-only (OR: 2.5; 95% CI: 1.23-5.00) patients. PSO-SH patients were at significantly higher risk of having Crohn's disease (OR: 4.6-11.9; 95% CI). Data revealed the highest overall genetic risk score for PSO-SH patients (PSO-polygenic risk score; 108.22), followed by PSO (101.18), HS (99.84), and healthy controls (98.58). High non-human leukocyte antigen scores were associated with an increased risk for developing both PSO and HS, indicating a distinct biological profile compared to HS-only and PSO-only individuals. LIMITATIONS: Some clinical information was collected retrospectively. CONCLUSIONS: This study highlights a shared genetic susceptibility of HS and PSO at non-human leukocyte antigen loci. Recognizing PSO-SH patients as a distinct patient group with high morbidity and increased risk for developing Crohn's disease will help to improve patient management.","journal":"Journal of the American Academy of Dermatology","year":2025,"id":517864,"datarank":0.33526174238617273,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.02334551113419733,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.02334551113419733,"corpus_percentile":48.302003558443566,"corpus_rank":6684,"citation_count":7,"citer_count":7,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.6003,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1384803,"name":"Kareem G. Elhage","orcid":"0000-0002-2637-9341","position":1,"is_corresponding":false},{"id":1385293,"name":"Andrea Leung","orcid":null,"position":2,"is_corresponding":false},{"id":617993,"name":"Albert T. Young","orcid":"0000-0002-4088-2488","position":3,"is_corresponding":false},{"id":56453,"name":"Mark Gregory","orcid":"0000-0003-4149-4724","position":4,"is_corresponding":false},{"id":274753,"name":"Indra Adrianto","orcid":"0000-0002-9973-3057","position":5,"is_corresponding":false},{"id":259859,"name":"Li Zhou","orcid":"0000-0002-6211-1860","position":6,"is_corresponding":false},{"id":1385294,"name":"Qing-Sheng Mi","orcid":null,"position":7,"is_corresponding":false},{"id":865046,"name":"Sugandh Kumar","orcid":"0000-0001-7000-4718","position":8,"is_corresponding":false},{"id":1196974,"name":"Faye Orcales","orcid":"0000-0002-9326-1001","position":9,"is_corresponding":false},{"id":865048,"name":"Samuel Yeroushalmi","orcid":"0000-0002-8327-3279","position":10,"is_corresponding":false},{"id":1384804,"name":"Kathryn Haran","orcid":"0000-0001-8166-4826","position":11,"is_corresponding":false},{"id":261948,"name":"Jared Liu","orcid":"0000-0001-8481-3129","position":12,"is_corresponding":false},{"id":258593,"name":"Haley B. Naik","orcid":"0000-0003-2760-3904","position":13,"is_corresponding":false},{"id":94228,"name":"Wilson Liao","orcid":"0000-0001-7883-6439","position":14,"is_corresponding":false},{"id":899460,"name":"Christian Posch","orcid":"0000-0003-0296-3567","position":15,"is_corresponding":false},{"id":1384802,"name":"Antonia Wiala","orcid":"0000-0003-1029-2302","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-19T02:49:04.756302Z","pmid":"39929305","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}