{"doi":"10.1016/j.jaad.2021.09.069","title":"Epicardial adipose tissue volume is greater in men with severe psoriasis, implying an increased cardiovascular disease risk: A cross-sectional study","abstract":null,"journal":"Journal of the American Academy of Dermatology","year":2022,"id":648624,"datarank":0.981979693204463,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.5326198521713643,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.5326198521713643,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":19,"citers_with_citation_signal":17,"citers_with_endowment":17,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1690491,"name":"Stephen J. Neville","orcid":null,"position":1,"is_corresponding":false},{"id":1690493,"name":"Mohamed Sayyouh","orcid":null,"position":2,"is_corresponding":false},{"id":350594,"name":"James T. Elder","orcid":"0000-0003-4215-3294","position":3,"is_corresponding":false},{"id":350593,"name":"Rajan P. Nair","orcid":"0000-0002-7842-823X","position":4,"is_corresponding":false},{"id":12822,"name":"Johann E. Gudjonsson","orcid":null,"position":5,"is_corresponding":false},{"id":1461593,"name":"Tianwen Ma","orcid":"0000-0003-2741-7706","position":6,"is_corresponding":false},{"id":309299,"name":"Ella A. Kazerooni","orcid":"0000-0001-5859-8744","position":7,"is_corresponding":false},{"id":521925,"name":"Melvyn Rubenfire","orcid":"0000-0002-0290-7154","position":8,"is_corresponding":false},{"id":1690507,"name":"Prachi P. Agarwal","orcid":null,"position":9,"is_corresponding":false},{"id":1690489,"name":"Charles N. Ellis","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Epicardial adipose tissue volume is greater in men with severe psoriasis, implying an increased cardiovascular disease risk: A cross-sectional study","abstract":"<h4>Background</h4>Patients with psoriasis have elevated risk of coronary artery disease.<h4>Objective</h4>Do patients with severe psoriasis have larger epicardial adipose tissue volumes (EAT-V) that are associated with cardiovascular risk?<h4>Methods</h4>For this cross-sectional study, we recruited dermatology patients with severe psoriasis and control patients without psoriasis or rheumatologic disease themselves or in a first-degree relative. Participants aged 34 to 55 years without known coronary artery disease or diabetes mellitus underwent computed tomography (CT); EAT-V was obtained from noncontrast CT heart images.<h4>Results</h4>Twenty-five patients with psoriasis (14 men, 11 women) and 16 controls (5 men, 11 women) participated. Groups had no statistical difference in age, body mass index, various cardiovascular risk factors (except high-sensitivity C-reactive protein in men), CT-determined coronary artery calcium scores or plaque, or family history of premature cardiovascular disease. Mean EAT-V was greater in the psoriasis group compared to controls (P = .04). There was no statistically significant difference among women; however, male patients with psoriasis had significantly higher EAT-V than controls (P = .03), even when corrected for elevated high-sensitivity C-reactive protein (P = .05).<h4>Limitations</h4>A single-center convenience sample may not be representative.<h4>Conclusion</h4>Males with psoriasis without known coronary disease or diabetes had greater EAT-V than controls. EAT-V may be an early identifier of those at increased risk for cardiovascular events.","is_dataset_classified":null,"base_score":2.995732273553991,"endowment":2.995732273553991,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34678237","pmcid":null,"openalex_id":"https://openalex.org/W3206159867","authors":[],"funders":[{"funder_name":"NIAMS NIH HHS","grant_id":"RC1 AR058315","title":null},{"funder_name":"NIAMS NIH HHS","grant_id":"R01 AR050511","title":null},{"funder_name":"NIAMS NIH HHS","grant_id":"R01 AR065183","title":null},{"funder_name":"NHGRI NIH HHS","grant_id":"U01 HG005924","title":null},{"funder_name":"NIAMS NIH HHS","grant_id":"R01 AR042742","title":null},{"funder_name":"National Psoriasis Foundation","grant_id":"","title":null}],"total_grants":6,"fwci":2.3382,"citation_percentile":0.90206105,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2022,"count":5},{"year":2023,"count":5},{"year":2024,"count":6},{"year":2025,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0190962221026487?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0190962221026487?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jaad.2021.09.069","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34678237","host_type":"repository"}],"fields_of_study":["Cardiovascular Disease and Adiposity","Adipokines, Inflammation, and Metabolic Diseases","IL-33, ST2, and ILC Pathways"],"mesh_terms":["Adipose Tissue","Adult","C-Reactive Protein","Cardiovascular Diseases","Coronary Artery Disease","Cross-Sectional Studies","Female","Humans","Male","Middle Aged","Pericardium","Psoriasis","Risk Factors","Tomography, X-Ray Computed","Vascular Calcification"],"keywords":["Medicine","Psoriasis","Diabetes mellitus","Internal medicine","Coronary artery disease","Body mass index","Cardiology","Cross-sectional study","Disease","Pathology","Dermatology","Endocrinology","Sex differences","Cardiovascular Risk","Epicardial Adipose Tissue","Coronary Ct Angiography","Ct Coronary Calcium Score","Predictors Of Cardiovascular Disease"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T02:48:20.145090Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}