{"doi":"10.1016/j.jaad.2020.06.1024","title":"Delineation of clinical and biological factors associated with cutaneous squamous cell carcinoma among patients with chronic lymphocytic leukemia","abstract":"BACKGROUND: The incidence of cutaneous squamous cell carcinoma (SCC) in patients with chronic lymphocytic leukemia (CLL) is significantly higher compared with age- and sex-matched controls. OBJECTIVE: To evaluate the association of factors associated with SCC risk. METHODS: Clinical CLL and SCC data were obtained from Mayo Clinic CLL Resource and self-reported questionnaires among patients with newly diagnosed CLL. We computed the CLL International Prognostic Index (CLL-IPI) from CLL prognostic factors, and a polygenic risk score from SCC susceptibility variants. We used Cox regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS: Among 1269 patients with CLL, the median follow-up was 7 years, and SCC subsequently developed in 124 patients. Significant associations with SCC risk were history of skin cancer (HR=4.80; 95% CI: 3.37-6.83), CLL-IPI (HR=1.42; 95% CI: 1.13-1.80), and polygenic risk score (HR=2.58; 95% CI: 1.50-4.43). In a multivariable model, these factors were independent predictors (C statistic = 0.69; 95% CI: 0.62-0.76). T-cell immunosuppressive treatments were also associated with SCC risk (HR=2.29; 95% CI: 1.47-3.55; adjusted for age, sex, and prior SCC). LIMITATIONS: The sample size decreases when combining all risk factors in a single model. CONCLUSION: SCC risk includes history of skin cancer, an aggressive disease at time of CLL diagnosis, receiving T-cell immunosuppressive treatments, and high polygenic risk score. Future studies should develop prediction models that include these factors to improved screening guidelines.","journal":"Journal of the American Academy of Dermatology","year":2020,"id":90134,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.651,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":454794,"name":"Abdul Rishi","orcid":"0000-0002-9074-9837","position":1,"is_corresponding":false},{"id":300279,"name":"Sara J. Achenbach","orcid":null,"position":2,"is_corresponding":false},{"id":420931,"name":"Kari G. Rabe","orcid":"0000-0002-7313-1875","position":3,"is_corresponding":false},{"id":451444,"name":"Neil E. Kay","orcid":"0000-0002-5951-5055","position":4,"is_corresponding":false},{"id":285630,"name":"Tait D. Shanafelt","orcid":"0000-0002-7106-5202","position":5,"is_corresponding":false},{"id":454795,"name":"Wei Ding","orcid":"0000-0001-9811-4601","position":6,"is_corresponding":false},{"id":455731,"name":"Joe F. Leis","orcid":null,"position":7,"is_corresponding":false},{"id":304439,"name":"Aaron D. Norman","orcid":"0000-0002-4208-2708","position":8,"is_corresponding":false},{"id":454796,"name":"Timothy G. Call","orcid":"0000-0002-8465-9587","position":9,"is_corresponding":false},{"id":302818,"name":"James R. Cerhan","orcid":"0000-0002-7482-178X","position":10,"is_corresponding":false},{"id":437794,"name":"Sameer A. Parikh","orcid":"0000-0002-3221-7314","position":11,"is_corresponding":false},{"id":454797,"name":"Christian L. Baum","orcid":"0000-0001-9447-4589","position":12,"is_corresponding":false},{"id":264807,"name":"Susan L. Slager","orcid":"0000-0002-5173-4712","position":13,"is_corresponding":false},{"id":404947,"name":"Geffen Kleinstern","orcid":"0000-0001-6148-0421","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-18T22:02:48.683291Z","pmid":"32682027","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}