{"doi":"10.1016/j.jaad.2018.09.062","title":"Human oncoviruses: Mucocutaneous manifestations, pathogenesis, therapeutics, and prevention","abstract":null,"journal":"Journal of the American Academy of Dermatology","year":2019,"id":685022,"datarank":0.5606504427425053,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"self_citation_contribution":0.5606504427425053,"citation_network_contribution":0.0,"self_endowment_contribution":0.5606504427425053,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":4,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1789693,"name":"Uyen Ngoc Mui","orcid":null,"position":1,"is_corresponding":false},{"id":1789694,"name":"Ramya Vangipuram","orcid":null,"position":2,"is_corresponding":false},{"id":1789695,"name":"Peter L. Rady","orcid":null,"position":3,"is_corresponding":false},{"id":284629,"name":"Stephen K. Tyring","orcid":"0000-0002-3337-0580","position":4,"is_corresponding":false},{"id":442507,"name":"Christopher T. Haley","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Human oncoviruses: Mucocutaneous manifestations, pathogenesis, therapeutics, and prevention","abstract":"In 1964, the first human oncovirus, Epstein-Barr virus, was identified in Burkitt lymphoma cells. Since then, 6 other human oncoviruses have been identified: human papillomavirus, Merkel cell polyomavirus, hepatitis B and C viruses, human T-cell lymphotropic virus-1, and human herpesvirus-8. These viruses are causally linked to 12% of all cancers, many of which have mucocutaneous manifestations. In addition, oncoviruses are associated with multiple benign mucocutaneous diseases. Research regarding the pathogenic mechanisms of oncoviruses and virus-specific treatment and prevention is rapidly evolving. Preventative vaccines for human papillomavirus and hepatitis B virus are already available. This review discusses the mucocutaneous manifestations, pathogenesis, diagnosis, treatment, and prevention of oncovirus-related diseases. The first article in this continuing medical education series focuses on diseases associated with human papillomavirus and Merkel cell polyomavirus, while the second article in the series focuses on diseases associated with hepatitis B and C viruses, human T-cell lymphotropic virus-1, human herpesvirus-8, and Epstein-Barr virus.","is_dataset_classified":null,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"datacite_reuse_total":4,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30502418","pmcid":null,"openalex_id":"https://openalex.org/W2902217789","authors":[],"funders":[],"total_grants":0,"fwci":1.3985,"citation_percentile":0.8552287,"influential_citations":0,"citation_trend":[{"year":2019,"count":3},{"year":2020,"count":5},{"year":2021,"count":9},{"year":2022,"count":9},{"year":2023,"count":4},{"year":2024,"count":7},{"year":2025,"count":1},{"year":2026,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0190962218329657?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0190962218329657?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jaad.2018.09.062","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30502418","host_type":"repository"}],"fields_of_study":["Polyomavirus and related diseases","Viral-associated cancers and disorders","Animal Virus Infections Studies","Biopsy, Needle","Education, Medical, Continuing","Female","Humans","Immunohistochemistry","Male","Merkel cell polyomavirus","Neoplasm Invasiveness","Papillomaviridae","Primary Prevention","Prognosis","Retroviridae","Risk Assessment","Skin Neoplasms","Survival Analysis","Tumor Virus Infections"],"mesh_terms":["Biopsy, Needle","Education, Medical, Continuing","Female","Humans","Immunohistochemistry","Male","Neoplasm Invasiveness","Primary Prevention","Prognosis","Retroviridae","Skin Neoplasms","Tumor Virus Infections","Survival Analysis","Risk Assessment","Papillomaviridae","Merkel cell polyomavirus"],"keywords":["Merkel cell polyomavirus","Mucocutaneous zone","Oncovirus","Medicine","Virology","Virus","Immunology","Hepatitis B virus","Tumor Virus","Epstein–Barr virus","Pathogenesis","Carcinogenesis","Cancer","Pathology","Merkel cell carcinoma","Disease","Carcinoma","Internal medicine","Human papillomavirus","Cervical cancer","Vaginal Cancer","Anal Cancer","Penile Cancer","Oropharyngeal Cancer","Vulvar Cancer"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.14906139.v1","title":"Additional file 1 of Reciprocal transactivation of Merkel cell polyomavirus and high-risk human papillomavirus promoter activities and increased expression of their oncoproteins","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.14906139","title":"Additional file 1 of Reciprocal transactivation of Merkel cell polyomavirus and high-risk human papillomavirus promoter activities and increased expression of their oncoproteins","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.14906142.v1","title":"Additional file 2 of Reciprocal transactivation of Merkel cell polyomavirus and high-risk human papillomavirus promoter activities and increased expression of their oncoproteins","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.14906142","title":"Additional file 2 of Reciprocal transactivation of Merkel cell polyomavirus and high-risk human papillomavirus promoter activities and increased expression of their oncoproteins","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T15:35:21.742418Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}