{"doi":"10.1016/j.jaac.2025.04.010","title":"Associations Between a Genetic Liability Toward Externalizing and Behavioral Outcomes Spanning Toddlerhood Through Early Adulthood in Five Developmental Cohorts","abstract":"OBJECTIVE: Understanding how genetic risk unfolds across development will be important for using genetics to inform prevention and early intervention. The current study leverages information from 5 large datasets to characterize behavioral manifestations of a genetic liability toward externalizing from ages 6 months to 26 years. METHOD: ) to estimate associations of genetic liability with relevant phenotypes within and across developmental periods, ranging from toddlerhood to early adulthood. We used data from 5 population- and family-based datasets spanning 3 countries. RESULTS: was associated with higher levels of substance use and problems beginning in early adolescence through early adulthood, including alcohol and illicit drug use. There was minimal evidence for sex interactions. CONCLUSION: A genetic liability toward externalizing is associated a wide array of behaviors and psychiatric/substance use outcomes beginning as early as childhood and through emerging adulthood. The early emergence and breadth of behaviors associated with a genetic liability toward externalizing could inform prevention and intervention. PLAIN LANGUAGE SUMMARY: This study leverages information from 5 large datasets to characterize behavioral manifestations of a genetic liability toward externalizing symptoms from ages 6 months to 26 years. A genetic liability toward externalizing symptoms was associated with a wide array of externalizing behaviors and psychiatric/substance use outcomes beginning as early as childhood and through emerging adulthood. The early emergence and breadth of behaviors associated with a genetic liability toward externalizing could inform prevention and intervention. STUDY REGISTRATION INFORMATION: Mapping Genetic Risk for Externalizing Behavior in Childhood, Adolescence, and Early Adulthood; https://osf.io/7g4ak/.","journal":"Journal of the American Academy of Child & Adolescent Psychiatry","year":2025,"id":530656,"datarank":0.3130647547709906,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.04430083438678232,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.04430083438678232,"corpus_percentile":46.368066836853096,"corpus_rank":6934,"citation_count":5,"citer_count":3,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5582,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":618521,"name":"Holly E. Poore","orcid":"0000-0003-0235-6070","position":1,"is_corresponding":false},{"id":434518,"name":"Sarah J. Brislin","orcid":"0000-0003-4303-8124","position":2,"is_corresponding":false},{"id":320080,"name":"Peter B. Barr","orcid":"0000-0001-9321-657X","position":3,"is_corresponding":false},{"id":256430,"name":"Fazil Alıev","orcid":"0000-0001-8357-4699","position":4,"is_corresponding":false},{"id":230719,"name":"Stephanie Zellers","orcid":"0000-0001-8927-3483","position":5,"is_corresponding":false},{"id":377313,"name":"Gretchen Saunders","orcid":"0000-0001-5972-9785","position":6,"is_corresponding":false},{"id":446084,"name":"Jessica E. Salvatore","orcid":"0000-0001-5504-5087","position":7,"is_corresponding":false},{"id":14729,"name":"Scott Vrieze","orcid":"0000-0003-3861-7930","position":8,"is_corresponding":false},{"id":257616,"name":"K. Paige Harden","orcid":"0000-0002-1557-6737","position":9,"is_corresponding":false},{"id":230002,"name":"Abraham A. Palmer","orcid":"0000-0003-3634-0747","position":10,"is_corresponding":false},{"id":1311043,"name":"Anu Raevuori","orcid":"0000-0001-7704-9441","position":11,"is_corresponding":false},{"id":264593,"name":"Antti Latvala","orcid":"0000-0001-5695-117X","position":12,"is_corresponding":false},{"id":230703,"name":"Danielle M. Dick","orcid":"0000-0002-1636-893X","position":13,"is_corresponding":false},{"id":1149115,"name":"Maia Choi","orcid":"0009-0007-9918-4901","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-19T02:51:05.836974Z","pmid":"40280543","pmcid":"PMC13267360","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}