{"doi":"10.1016/j.it.2024.08.008","title":"Emerging roles of astrocytes as immune effectors in the central nervous system","abstract":null,"journal":"Trends in Immunology","year":2024,"id":608832,"datarank":0.6090664515819629,"base_score":4.060443010546419,"endowment":4.060443010546419,"self_citation_contribution":0.6090664515819629,"citation_network_contribution":0.0,"self_endowment_contribution":0.6090664515819629,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":57,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":29917,"name":"Shane A. Liddelow","orcid":"0000-0002-0840-1437","position":1,"is_corresponding":false},{"id":1201664,"name":"Theodore M. Fisher","orcid":"0000-0002-4048-3428","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Emerging roles of astrocytes as immune effectors in the central nervous system","abstract":"The astrocyte, a major glial cell type in the central nervous system (CNS), is widely regarded as a functionally diverse mediator of homeostasis. During development and throughout adulthood, astrocytes have essential roles, such as providing neuron metabolic support, modulating synaptic function, and maintaining the blood-brain barrier (BBB). Recent evidence continues to underscore their functional heterogeneity and importance for CNS maintenance, as well as how these cells ensure optimal CNS and immune responses to disease, acute trauma, and infection. Advances in our understanding of neuroimmune interactions complement our knowledge of astrocyte functional heterogeneity, where astrocytes are now regarded as key effectors and propagators of immune signaling. This shift in perspective highlights the role of astrocytes not merely as support cells, but as active participants in CNS immune responses.","is_dataset_classified":null,"base_score":4.060443010546419,"endowment":4.060443010546419,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39332912","pmcid":null,"openalex_id":"https://openalex.org/W4402934853","authors":[],"funders":[],"total_grants":0,"fwci":9.7306,"citation_percentile":0.98731646,"influential_citations":0,"citation_trend":[{"year":2024,"count":3},{"year":2025,"count":33},{"year":2026,"count":21}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1471490624001947?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1471490624001947?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.it.2024.08.008","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39332912","host_type":"repository"}],"fields_of_study":["Neuroinflammation and Neurodegeneration Mechanisms","Immune cells in cancer","Tryptophan and brain disorders","Astrocytes","Humans","Animals","Central Nervous System","Blood-Brain Barrier","Neuroimmunomodulation","Homeostasis","Signal Transduction"],"mesh_terms":["Animals","Astrocytes","Blood-Brain Barrier","Central Nervous System","Homeostasis","Humans","Neuroimmunomodulation","Signal Transduction"],"keywords":["Immunology","Central nervous system","Effector","Immune system","Neuroscience","Astrocyte","Biology","Medicine","Cytokine","Inflammation","T cell","Chemokine","Antigen presentation","Glia","Reactive Astrocyte"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T22:52:21.630325Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}