{"doi":"10.1016/j.isci.2025.112342","title":"Astrocytic FABP5 mediates retrograde endocannabinoid transport at central synapses","abstract":"Endocannabinoids (eCBs) regulate synaptic function via cannabinoid receptors. While eCB signaling is well understood, the mechanisms underlying eCB synaptic transport are poorly characterized. Using 2-arachidonoylglycerol (2-AG)-mediated depolarization-induced suppression of inhibition (DSI) in the hippocampus as a readout of retrograde eCB signaling, we demonstrate that the deletion of fatty acid binding protein 5 (FABP5) impairs DSI. In FABP5 KO mice, DSI was rescued by re-expressing wild-type FABP5 but not an FABP5 mutant that does not bind 2-AG. Importantly, the deletion of astrocytic FABP5 blunted DSI, which was rescued by its re-expression in the astrocytes of FABP5 KO mice. Neuronal FABP5 was dispensable for 2-AG signaling. DSI was also rescued by expressing a secreted FABP5 variant but not by FABP7, an astrocytic FABP that does not undergo secretion. Our results demonstrate that extracellular FABP5 of astrocytic origin controls 2-AG transport and that FABP5 is adapted to coordinate intracellular and synaptic eCB transport.","journal":"iScience","year":2025,"id":519316,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9563,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":884692,"name":"Mohammad Fauzan","orcid":"0009-0007-3595-6490","position":1,"is_corresponding":false},{"id":1081654,"name":"Keith M. Studholme","orcid":"0000-0002-0037-514X","position":2,"is_corresponding":false},{"id":1081651,"name":"Chris Gordon","orcid":"0000-0002-2784-5201","position":3,"is_corresponding":false},{"id":885274,"name":"Sherrye T. Glaser","orcid":null,"position":4,"is_corresponding":false},{"id":328288,"name":"Roh‐Yu Shen","orcid":"0000-0002-0421-3260","position":5,"is_corresponding":false},{"id":500541,"name":"Iwao Ojima","orcid":"0000-0002-3628-1161","position":6,"is_corresponding":false},{"id":884693,"name":"Martin Kaczocha","orcid":"0000-0002-2527-1398","position":7,"is_corresponding":false},{"id":328287,"name":"Samir Haj‐Dahmane","orcid":"0000-0002-6012-7199","position":8,"is_corresponding":false},{"id":434131,"name":"Saida Oubraim","orcid":"0000-0003-4930-2133","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:49:18.751199Z","pmid":"40292318","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}