{"doi":"10.1016/j.isci.2025.112243","title":"Neonatal gut microbiota succession in mice mapped over time, site, injury and single immunoglobulin interleukin-1 related receptor genotype","abstract":"<h2>Summary</h2> Microbial succession during postnatal gut development in mice is likely impacted by site of sampling, time, intestinal injury, and host genetics. We investigated this in wild-type and <i>Sigirr</i> transgenic mice that encode the p.Y168X mutation identified in a neonate with necrotizing enterocolitis (NEC). Temporal profiling of the ileal and colonic microbiome after birth to weaning revealed a clear pattern of progression from a less diverse, Proteobacteria/Escherichia_Shigella dominant community to a more diverse, Firmicutes/Bacteroidetes dominant community. Formula milk feeding, a risk factor for necrotizing enterocolitis, decreased Firmicutes and increased Proteobacteria leading to enrichment of bacterial genes denoting exaggerated glycolysis and increased production of acetate and lactate. <i>Sigirr</i> transgenic mice exhibited modest baseline differences in microbiota composition but exaggerated formula feeding-induced dysbiosis, mucosal inflammation, and villus injury. Postnatal intestinal microbiota succession in mice resembles human neonates and is shaped by developmental maturity, ileal vs. colonic sampling, formula feeding, and <i>Sigirr</i> genotype.","journal":"iScience","year":2025,"id":522909,"datarank":0.25900300338678534,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.017587316521670254,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.017587316521670254,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":3,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9572,"is_data_producer":true,"deposit_databanks":{"figshare":["10.6084/m9.figshare.28570697.v2"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":692028,"name":"Wei Yu","orcid":"0000-0002-1174-596X","position":1,"is_corresponding":false},{"id":1137741,"name":"Hao Xuan","orcid":null,"position":2,"is_corresponding":false},{"id":530845,"name":"Ishfaq Ahmed","orcid":"0000-0001-9256-832X","position":3,"is_corresponding":false},{"id":274868,"name":"Cuncong Zhong","orcid":"0000-0002-8777-082X","position":4,"is_corresponding":false},{"id":225983,"name":"Michael J. Morowitz","orcid":"0000-0001-8172-637X","position":5,"is_corresponding":false},{"id":1395403,"name":"Mathew Brian Rogers","orcid":null,"position":6,"is_corresponding":false},{"id":1395404,"name":"Mark Ivan Attard","orcid":null,"position":7,"is_corresponding":false},{"id":488894,"name":"Venkatesh Sampath","orcid":"0000-0001-7917-6508","position":8,"is_corresponding":false},{"id":530846,"name":"Shahid Umar","orcid":"0000-0003-0579-6813","position":0,"is_corresponding":true}],"reference_count":87,"raw_metadata":null,"created_at":"2026-07-19T02:49:58.707747Z","pmid":"40248118","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}