{"doi":"10.1016/j.isci.2024.111137","title":"Dysfunctional bronchoalveolar effector memory CD8+ T cells in tuberculosis-exposed people living with antiretroviral-naïve HIV infection","abstract":"HIV causes susceptibility to respiratory pathogens, including tuberculosis (TB), but the underlying immunological mechanisms remain incompletely understood. We obtained whole blood and bronchoalveolar lavage (BAL) from TB-exposed people in the presence or absence of antiretroviral-naïve HIV co-infection. Bulk transcriptional profiling demonstrated compartment-specific enrichment of immunological processes. Systems-level deconvolution of whole blood from people living with HIV identified elevated type I and type II interferon cytokine activity and T cell proliferation. Transcriptional modules derived from both peripheral blood and sorted BAL immune cells demonstrated an increased frequency of effector memory CD8 T cells in whole BAL samples. Both compartments displayed reduced induction of CD8 T-cell-derived interleukin-17A (IL-17A) in people with HIV, associated with elevated T cell regulatory molecule expression. The data suggest that dysfunctional CD8 T cell responses in uncontrolled HIV may contribute to compromised respiratory immunity to pathogens, a process that could be modulated by host-directed therapies that target CD8 T cell effector functions.","journal":"iScience","year":2024,"id":504797,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9492,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1301340,"name":"Helgard Claassen","orcid":null,"position":1,"is_corresponding":false},{"id":572301,"name":"Sharon Khuzwayo","orcid":"0000-0003-4482-5955","position":2,"is_corresponding":false},{"id":109702,"name":"Valentin Voillet","orcid":"0000-0002-5751-3881","position":3,"is_corresponding":false},{"id":698619,"name":"Anneta Naidoo","orcid":null,"position":4,"is_corresponding":false},{"id":1355686,"name":"Jule S. Spillner","orcid":null,"position":5,"is_corresponding":false},{"id":572304,"name":"Kennedy Nyamande","orcid":"0000-0002-8515-0774","position":6,"is_corresponding":false},{"id":572305,"name":"Dilshaad Fakey Khan","orcid":"0000-0003-0665-792X","position":7,"is_corresponding":false},{"id":573059,"name":"Priya Maharaj","orcid":null,"position":8,"is_corresponding":false},{"id":572306,"name":"Mohammed Mitha","orcid":"0000-0003-1916-8201","position":9,"is_corresponding":false},{"id":573061,"name":"Zoey Mhlane","orcid":null,"position":10,"is_corresponding":false},{"id":406977,"name":"Farina Karim","orcid":"0000-0001-9698-016X","position":11,"is_corresponding":false},{"id":52018,"name":"Erica Andersen‐Nissen","orcid":"0000-0001-9213-920X","position":12,"is_corresponding":false},{"id":252002,"name":"Thumbi Ndung’u","orcid":"0000-0003-2962-3992","position":13,"is_corresponding":false},{"id":575579,"name":"Gabriele Pollara","orcid":"0000-0001-5772-0322","position":14,"is_corresponding":false},{"id":250374,"name":"Emily Wong","orcid":"0000-0003-4755-5380","position":15,"is_corresponding":false},{"id":572302,"name":"Maphe Mthembu","orcid":"0000-0003-1077-6403","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:10:39.578471Z","pmid":"39563891","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}