{"doi":"10.1016/j.isci.2024.110752","title":"A global transcriptional atlas of the effect of acute sleep deprivation in the mouse frontal cortex","abstract":null,"journal":"iScience","year":2024,"id":632495,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":52.7,"corpus_rank":6342,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1639549,"name":"Elena Zuin","orcid":null,"position":1,"is_corresponding":false},{"id":31857,"name":"Dario Righelli","orcid":"0000-0003-1504-3583","position":2,"is_corresponding":false},{"id":1639550,"name":"Elizabeth Medina","orcid":null,"position":3,"is_corresponding":false},{"id":493589,"name":"Hannah Schoch","orcid":"0000-0001-5527-0284","position":4,"is_corresponding":false},{"id":257400,"name":"Kristan Singletary","orcid":null,"position":5,"is_corresponding":false},{"id":1298790,"name":"Christine Muheim","orcid":"0000-0002-1010-2516","position":6,"is_corresponding":false},{"id":257401,"name":"Marcos G. 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In this study, we present the first simultaneous bulk and single-nuclear RNA sequencing characterization of the effects of SD in the male mouse frontal cortex. We show that SD predominantly affects glutamatergic neurons, specifically in layers 4 and 5, and produces isoform switching of over 1500 genes, particularly those involved in splicing and RNA binding. At both the global and cell-type specific level, SD has a large repressive effect on transcription, downregulating thousands of genes and transcripts. As a resource we provide extensive characterizations of cell-types, genes, transcripts, and pathways affected by SD. We also provide publicly available tutorials aimed at allowing readers adapt analyses performed in this study to their own datasets.","is_dataset_classified":null,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39280614","pmcid":"PMC11402219","openalex_id":"https://openalex.org/W4401665295","authors":[],"funders":[{"funder_name":"National Institute of Neurological Disorders and Stroke","grant_id":"R56NS124805","title":null},{"funder_name":"Chan Zuckerberg Initiative","grant_id":"CZF2019-002443","title":null},{"funder_name":"National Institute of General Medical Sciences","grant_id":"R35GM147020","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"F99 NS135815","title":null},{"funder_name":"National Institutes of Health","grant_id":"1R56NS124805-01A1","title":"Understanding the interaction between sleep and SHANK3/B-catenin signaling in Autism"},{"funder_name":"National Institutes of Health","grant_id":"5R35GM147020-03","title":"The role of sleep on chromatin and transcriptional regulation across vertebrate evolution."},{"funder_name":"Silicon Valley Community Foundation","grant_id":"","title":null}],"total_grants":7,"fwci":2.6437,"citation_percentile":0.90814943,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":4},{"year":2026,"count":5}],"oa_status":"gold","license":"CC BY NC","oa_locations":[{"url":"https://doi.org/10.1016/j.isci.2024.110752","host_type":"journal"},{"url":"https://doi.org/10.1016/j.isci.2024.110752","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2589004224019771?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2589004224019771?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39280614","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11402219","host_type":"repository"},{"url":"https://hdl.handle.net/11577/3533621","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11402219/pdf/main.pdf","host_type":"repository"},{"url":"https://www.research.unipd.it/bitstream/11577/3533621/1/PIIS2589004224019771.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11402219","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11402219?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1016/j.isci.2024.110752","host_type":""},{"url":"https://hdl.handle.net/11588/1012585","host_type":""}],"fields_of_study":["Adipose Tissue and Metabolism","Single-cell and spatial transcriptomics","Immune Cell Function and Interaction","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":[],"keywords":["Sleep deprivation","Neuroscience","Glutamatergic","RNA splicing","Biology","Alternative splicing","Transcriptome","Frontal cortex","Gene","Molecular neuroscience","Sleep (system call)","Transcription factor","RNA","Gene isoform","Gene expression","Genetics","Circadian rhythm","Glutamate receptor","Molecular biology","Transcriptomics","Omics","Molecular biology; Molecular neuroscience; Neuroscience; Omics; Transcriptomics","Article"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"geo"},{"name":"rrid"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T09:52:30.438681Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}