{"doi":"10.1016/j.isci.2024.109367","title":"The winged helix domain of MORF binds CpG islands and the TAZ2 domain of p300","abstract":"Acetylation of histones by lysine acetyltransferases (KATs) provides a fundamental mechanism by which chromatin structure and transcriptional programs are regulated. Here, we describe a dual binding activity of the first winged helix domain of human MORF KAT (MORF WH1 ) that recognizes the TAZ2 domain of p300 KAT (p300 TAZ2 ) and CpG rich DNA sequences. Structural and biochemical studies identified distinct DNA and p300 TAZ2 binding sites, allowing MORF WH1 to independently engage either ligand. Genomic data show that MORF/MOZ WH1 colocalizes with H3K18ac, a product of enzymatic activity of p300, on CpG rich promoters of target genes. Our findings suggest a functional cooperation of MORF and p300 KATs in transcriptional regulation.","journal":"iScience","year":2024,"id":455426,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9581,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":17619,"name":"Akinori Kanai","orcid":"0000-0003-1555-6768","position":1,"is_corresponding":false},{"id":1102531,"name":"Soumi Biswas","orcid":"0000-0002-6944-1475","position":2,"is_corresponding":false},{"id":1064984,"name":"Mohamed Reda Halawa","orcid":"0000-0002-6594-7479","position":3,"is_corresponding":false},{"id":1025152,"name":"Lei Zeng","orcid":"0000-0002-4236-6735","position":4,"is_corresponding":false},{"id":480147,"name":"Khan L. Cox","orcid":null,"position":5,"is_corresponding":false},{"id":111546,"name":"Michael G. Poirier","orcid":"0000-0002-1563-5792","position":6,"is_corresponding":false},{"id":228878,"name":"Ming‐Ming Zhou","orcid":"0000-0002-7049-0573","position":7,"is_corresponding":false},{"id":329463,"name":"Xiaobing Shi","orcid":"0000-0001-5242-8189","position":8,"is_corresponding":false},{"id":895326,"name":"Akihiko Yokoyama","orcid":"0000-0002-5639-8068","position":9,"is_corresponding":false},{"id":314067,"name":"Tatiana G. Kutateladze","orcid":"0000-0001-7375-6990","position":10,"is_corresponding":false},{"id":1055956,"name":"Dustin C. Becht","orcid":"0000-0003-3127-3418","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T02:03:17.458329Z","pmid":"38500836","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}