{"doi":"10.1016/j.isci.2024.109331","title":"Extensive dynamic changes in the human transcriptome and its circadian organization during prolonged bed rest","abstract":null,"journal":"iScience","year":2024,"id":589032,"datarank":0.377457894724134,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.017773603804378337,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.017773603804378337,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":7,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1507015,"name":"Carla Möller-Levet","orcid":null,"position":1,"is_corresponding":false},{"id":1507016,"name":"María-Ángeles Bonmatí-Carrión","orcid":null,"position":2,"is_corresponding":false},{"id":1507017,"name":"Emma E. Laing","orcid":null,"position":3,"is_corresponding":false},{"id":197393,"name":"Derk-Jan Dijk","orcid":null,"position":4,"is_corresponding":false},{"id":200947,"name":"Simon N. Archer","orcid":"0000-0002-9273-4647","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Extensive dynamic changes in the human transcriptome and its circadian organization during prolonged bed rest","abstract":"Physiological and molecular processes including the transcriptome change across the 24-h day, driven by molecular circadian clocks and behavioral and systemic factors. It is not known how the temporal organization of the human transcriptome responds to a long-lasting challenge. This may, however, provide insights into adaptation, disease, and recovery. We investigated the human 24-h time series transcriptome in 20 individuals during a 90-day constant bed rest protocol. We show that the protocol affected 91% of the transcriptome with 76% of the transcriptome still affected after 10 days of recovery. Dimensionality-reduction approaches revealed that many affected transcripts were associated with mRNA translation and immune function. The number, amplitude, and phase of rhythmic transcripts, including clock genes, varied significantly across the challenge. These findings of long-lasting changes in the temporal organization of the transcriptome have implications for understanding the mechanisms underlying health consequences of conditions such as microgravity and bed rest.","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38487016","pmcid":"PMC10937834","openalex_id":"https://openalex.org/W4392059188","authors":[],"funders":[{"funder_name":"Biotechnology and Biological Sciences Research Council","grant_id":"BB/N004981/1","title":"15 BEDREST Effects of bed rest on the circadian organisation of the human transcriptome as a model for temporal dysregulation in an ageing population"},{"funder_name":"European Space Agency","grant_id":"","title":null}],"total_grants":2,"fwci":2.4538,"citation_percentile":0.89256632,"influential_citations":0,"citation_trend":[{"year":2024,"count":3},{"year":2025,"count":5},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.isci.2024.109331","host_type":"journal"},{"url":"https://doi.org/10.1016/j.isci.2024.109331","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2589004224005522?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2589004224005522?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38487016","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10937834","host_type":"repository"},{"url":"https://doaj.org/article/8b2d3ec741cd4efe8451379b3e96bfa4","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10937834/pdf/main.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC10937834","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10937834?pdf=render","host_type":"Europe_PMC"},{"url":"https://doi.org/10.1016/j.isci.2024.110364","host_type":""},{"url":"http://dx.doi.org/10.1016/j.isci.2024.109331","host_type":""},{"url":"http://dx.doi.org/10.1016/j.isci.2024.110364","host_type":""},{"url":"https://doaj.org/article/a6b6672145eb42bb9fdd4db02058774c","host_type":""},{"url":"http://hdl.handle.net/10201/149946","host_type":""},{"url":"https://openresearch.surrey.ac.uk/esploro/outputs/journalArticle/Extensive-dynamic-changes-in-the-human/99941854702346","host_type":""}],"fields_of_study":["Spaceflight effects on biology","Circadian rhythm and melatonin","Genetics, Aging, and Longevity in Model Organisms","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":[],"keywords":["Transcriptome","Circadian rhythm","Biology","Circadian clock","Adaptation (eye)","CLOCK","Proteome","Computational biology","Gene","Bioinformatics","Neuroscience","Genetics","Gene expression","Medical research","Transcriptomics","Expression Study","Human Specimen","Science","Q","Correction","Article"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"geo"},{"name":"nct"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-23T11:59:52.370002Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}