{"doi":"10.1016/j.isci.2023.108572","title":"mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection","abstract":"SARS-CoV-2 infection and vaccination elicit potent immune responses. Our study presents a comprehensive multimodal single-cell analysis of blood from COVID-19 patients and healthy volunteers receiving the SARS-CoV-2 vaccine and booster. We profiled immune responses via transcriptional analysis and lymphocyte repertoire reconstruction. COVID-19 patients displayed an enhanced interferon signature and cytotoxic gene upregulation, absent in vaccine recipients. B and T cell repertoire analysis revealed clonal expansion among effector cells in COVID-19 patients and memory cells in vaccine recipients. Furthermore, while clonal αβ T cell responses were observed in both COVID-19 patients and vaccine recipients, expansion of clonal γδ T cells was found only in infected individuals. Our dataset enables side-by-side comparison of immune responses to infection versus vaccination, including clonal B and T cell responses. Our comparative analysis shows that vaccination induces a robust, durable clonal B and T cell responses, without the severe inflammation associated with infection.","journal":"iScience","year":2023,"id":332494,"datarank":0.7158211258480736,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.22710664514485115,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.22710664514485115,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":22,"citers_with_citation_signal":13,"citers_with_endowment":13,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9525,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":805080,"name":"Jasmine Shwetar","orcid":null,"position":1,"is_corresponding":false},{"id":253551,"name":"Joseph C. Devlin","orcid":"0000-0002-0003-4812","position":2,"is_corresponding":false},{"id":457605,"name":"Terkild B. Buus","orcid":"0000-0001-7180-6384","position":3,"is_corresponding":false},{"id":804000,"name":"Sophie L. Gray-Gaillard","orcid":"0000-0002-4884-5956","position":4,"is_corresponding":false},{"id":238059,"name":"Akiko Koide","orcid":"0000-0003-1796-7077","position":5,"is_corresponding":false},{"id":710782,"name":"Amber Cornelius","orcid":null,"position":6,"is_corresponding":false},{"id":550603,"name":"Marie I. Samanovic","orcid":"0000-0002-6987-2232","position":7,"is_corresponding":false},{"id":75639,"name":"Alberto Herrera","orcid":"0000-0003-4189-9051","position":8,"is_corresponding":false},{"id":36092,"name":"Eleni P. Mimitou","orcid":"0000-0001-9737-6394","position":9,"is_corresponding":false},{"id":344618,"name":"Chenzhen Zhang","orcid":"0000-0002-3671-3569","position":10,"is_corresponding":false},{"id":804002,"name":"Trishala Karmacharya","orcid":"0000-0002-9141-8802","position":11,"is_corresponding":false},{"id":553901,"name":"Ludovic Desvignes","orcid":"0000-0001-6246-0828","position":12,"is_corresponding":false},{"id":457616,"name":"Niels Ødum","orcid":"0000-0003-3135-5624","position":13,"is_corresponding":false},{"id":166,"name":"Peter Smibert","orcid":"0000-0003-0772-1647","position":14,"is_corresponding":false},{"id":3910,"name":"Robert J. Ulrich","orcid":"0000-0002-3217-5062","position":15,"is_corresponding":false},{"id":3883,"name":"Mark J. Mulligan","orcid":"0000-0001-7262-9746","position":16,"is_corresponding":false},{"id":75651,"name":"Shohei Koide","orcid":"0000-0001-5473-4358","position":17,"is_corresponding":false},{"id":2201,"name":"Kelly V. Ruggles","orcid":"0000-0002-0152-0863","position":18,"is_corresponding":false},{"id":72304,"name":"Ramin S. Herati","orcid":"0000-0003-2613-4050","position":19,"is_corresponding":false},{"id":75652,"name":"Sergei B. Koralov","orcid":"0000-0002-4843-3791","position":20,"is_corresponding":false},{"id":553902,"name":"Ellie Ivanova","orcid":"0000-0002-1850-9505","position":0,"is_corresponding":true}],"reference_count":97,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:09:30.139849Z","pmid":"38213787","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}