{"doi":"10.1016/j.isci.2023.106904","title":"CD200R signaling contributes to unfavorable tumor microenvironment through regulating production of chemokines by tumor-associated myeloid cells","abstract":"CD200 is overexpressed in many solid tumors and considered as an immune checkpoint molecule dampening cancer immunity. In this study, we found that CD200R −/− mice were significantly more potent in rejecting these CD200 + tumors. scRNA sequencing demonstrated that tumors from CD200R −/− mice had more infiltration of CD4 + and CD8 + T cells, and NK cells but less infiltration of neutrophils. Antibody depletion experiments revealed that immune effector cells are crucial in inhibiting tumor growth in CD200R −/− mice. Mechanistically, we found that CD200R signaling regulates the expression of chemokines in tumor-associated myeloid cells (TAMCs). In the absence of CD200R, TAMCs increased expression of CCL24 and resulted in increased infiltration of eosinophils, which contributes to anti-tumor activity. Overall, we conclude that CD200R signaling contributes to unfavorable TME through chemokine-dependent recruitment of immune suppressive neutrophils and exclusion of anti-cancer immune effectors. Our study has implications in developing CD200-CD200R targeted immunotherapy of solid tumors.","journal":"iScience","year":2023,"id":349516,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9485,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":763557,"name":"Fatemeh Talebian","orcid":"0000-0002-8336-0348","position":1,"is_corresponding":false},{"id":486530,"name":"Yang Li","orcid":"0000-0002-7677-9028","position":2,"is_corresponding":false},{"id":493714,"name":"Jianmin Zhu","orcid":"0009-0005-9878-7239","position":3,"is_corresponding":false},{"id":108380,"name":"Jin-Qing Liu","orcid":"0009-0001-6761-5400","position":4,"is_corresponding":false},{"id":1092704,"name":"Bolin Zhao","orcid":"0000-0003-3773-510X","position":5,"is_corresponding":false},{"id":905275,"name":"Sujit Basu","orcid":"0000-0002-8272-0807","position":6,"is_corresponding":false},{"id":269761,"name":"Xueliang Pan","orcid":"0000-0002-2342-3212","position":7,"is_corresponding":false},{"id":717228,"name":"Xi Chen","orcid":"0000-0002-2144-6584","position":8,"is_corresponding":false},{"id":395913,"name":"Pearlly S. Yan","orcid":"0000-0003-1965-4920","position":9,"is_corresponding":false},{"id":417798,"name":"William E. Carson","orcid":"0000-0001-7024-7533","position":10,"is_corresponding":false},{"id":642775,"name":"Gang Xin","orcid":"0000-0003-1963-505X","position":11,"is_corresponding":false},{"id":515128,"name":"Haitao Wen","orcid":"0000-0002-6363-2748","position":12,"is_corresponding":false},{"id":232998,"name":"Ruoning Wang","orcid":"0000-0001-9798-8032","position":13,"is_corresponding":false},{"id":270306,"name":"Zihai Li","orcid":"0000-0003-4603-927X","position":14,"is_corresponding":false},{"id":1092705,"name":"Qin Ma","orcid":"0000-0001-8575-6314","position":15,"is_corresponding":false},{"id":493715,"name":"Xue‐Feng Bai","orcid":"0000-0001-9476-8376","position":16,"is_corresponding":false},{"id":669718,"name":"Cho-Hao Lin","orcid":"0000-0002-6165-904X","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-19T01:12:14.919810Z","pmid":"37275530","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}