{"doi":"10.1016/j.isci.2022.104602","title":"Lipoxins reduce obesity-induced adipose tissue inflammation in 3D-cultured human adipocytes and explant cultures","abstract":", a specialized pro-resolving lipid mediator, was shown to reduce adipose inflammation and subsequently protects against obesity-induced systemic disease in mice. Here, we demonstrate that lipoxins reduce inflammation in 3D-cultured human adipocytes and adipose tissue explants from obese patients. Approximately 50% of patients responded particularly well to lipoxins by reducing inflammatory cytokines and promoting an anti-inflammatory M2 macrophage phenotype. Responding patients were characterized by elevated systemic levels of C-reactive protein, which causes inflammation in cultured human adipocytes. Responders appeared more prone to producing anti-inflammatory oxylipins and displayed elevated prostaglandin D2 levels, which has been interlinked with transcription of lipoxin-generating enzymes. Using explant cultures, this study provides the first proof-of-concept evidence supporting the therapeutic potential of lipoxins in reducing human adipose tissue inflammation. Our data further indicate that lipoxin treatment may require a tailored personalized-medicine approach.","journal":"iScience","year":2022,"id":263282,"datarank":0.5085192771861986,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.11266067774390968,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.11266067774390968,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":8,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9617,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":897019,"name":"Meenu Rohini Rajan","orcid":"0000-0003-3900-1206","position":1,"is_corresponding":false},{"id":919773,"name":"Madison Clark","orcid":"0000-0002-0156-3513","position":2,"is_corresponding":false},{"id":1065,"name":"Matthew Harms","orcid":"0000-0002-3395-1633","position":3,"is_corresponding":false},{"id":745716,"name":"Alankrita Rani","orcid":"0000-0003-3412-0994","position":4,"is_corresponding":false},{"id":659824,"name":"Jamie Kraft","orcid":"0000-0001-6336-9997","position":5,"is_corresponding":false},{"id":920247,"name":"David Tandio","orcid":null,"position":6,"is_corresponding":false},{"id":331805,"name":"Tong Shen","orcid":"0000-0002-6091-8783","position":7,"is_corresponding":false},{"id":376244,"name":"Kamil Borkowski","orcid":"0000-0003-3637-3450","position":8,"is_corresponding":false},{"id":6363,"name":"Oliver Fiehn","orcid":"0000-0002-6261-8928","position":9,"is_corresponding":false},{"id":245218,"name":"John W. Newman","orcid":"0000-0001-9632-6571","position":10,"is_corresponding":false},{"id":775692,"name":"Marianne Quiding‐Järbrink","orcid":null,"position":11,"is_corresponding":false},{"id":660848,"name":"Christina Biörserud","orcid":null,"position":12,"is_corresponding":false},{"id":919774,"name":"Peter Apelgren","orcid":"0000-0003-0451-7771","position":13,"is_corresponding":false},{"id":920248,"name":"Trude Staalesen","orcid":null,"position":14,"is_corresponding":false},{"id":919775,"name":"Carolina E. Hagberg","orcid":"0000-0002-5497-2855","position":15,"is_corresponding":false},{"id":850731,"name":"Jérémie Boucher","orcid":"0000-0001-9610-475X","position":16,"is_corresponding":false},{"id":897020,"name":"Ville Wallenius","orcid":"0000-0001-8668-3196","position":17,"is_corresponding":false},{"id":504449,"name":"Stephan Lange","orcid":"0000-0001-9361-6602","position":18,"is_corresponding":false},{"id":659822,"name":"Emma Börgeson","orcid":"0000-0002-2290-9472","position":19,"is_corresponding":false},{"id":659823,"name":"Matúš Soták","orcid":"0000-0002-9984-9340","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:26:29.321923Z","pmid":"35789845","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}