{"doi":"10.1016/j.isci.2021.102201","title":"Structure of a type IV CRISPR-Cas ribonucleoprotein complex","abstract":"We reveal the cryo-electron microscopy structure of a type IV-B CRISPR ribonucleoprotein (RNP) complex (Csf) at 3.9-Å resolution. The complex best resembles the type III-A CRISPR Csm effector complex, consisting of a Cas7-like (Csf2) filament intertwined with a small subunit (Cas11) filament, but the complex lacks subunits for RNA processing and target DNA cleavage. Surprisingly, instead of assembling around a CRISPR-derived RNA (crRNA), the complex assembles upon heterogeneous RNA of a regular length arranged in a pseudo-A-form configuration. These findings provide a high-resolution glimpse into the assembly and function of enigmatic type IV CRISPR systems, expanding our understanding of class I CRISPR-Cas system architecture, and suggesting a function for type IV-B RNPs that may be distinct from other class 1 CRISPR-associated systems.","journal":"iScience","year":2021,"id":163791,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9464,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":463337,"name":"Jack P. K. Bravo","orcid":"0000-0003-0456-0753","position":1,"is_corresponding":false},{"id":567562,"name":"Hannah N. Taylor","orcid":"0000-0002-5643-8998","position":2,"is_corresponding":false},{"id":567563,"name":"Jurre A. Steens","orcid":"0000-0001-9293-7228","position":3,"is_corresponding":false},{"id":567564,"name":"Ryan N. Jackson","orcid":"0000-0001-7403-3794","position":4,"is_corresponding":false},{"id":567565,"name":"Raymond H.J. Staals","orcid":"0000-0002-5741-9457","position":5,"is_corresponding":false},{"id":377366,"name":"David W. Taylor","orcid":"0000-0002-6198-1194","position":6,"is_corresponding":false},{"id":567561,"name":"Yi Zhou","orcid":"0000-0002-1650-4591","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-18T23:45:22.477398Z","pmid":"33733066","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}