{"doi":"10.1016/j.isci.2020.102009","title":"Association between conventional or blue-light-filtering intraocular lenses and survival in bilateral cataract surgery patients","abstract":"Circadian rhythms regulate adaptive alterations in mammalian physiology and are maximally entrained by the short wavelength blue spectrum; cataracts block the transmission of light, particularly blue light. Cataract surgery is performed with two types of intraocular lenses (IOL): (1) conventional IOL that transmit the entire visible spectrum and (2) blue-light-filtering (BF) IOL that block the short wavelength blue spectrum. We hypothesized that the transmission properties of IOL are associated with long-term survival. This retrospective cohort study of a 15-hospital healthcare system identified 9,108 participants who underwent bilateral cataract surgery; 3,087 were implanted with conventional IOL and 6,021 received BF-IOL. Multivariable Cox proportional hazards models that included several a priori determined subgroup and sensitivity analyses yielded estimates supporting that conventional IOL compared with BF-IOL may be associated with significantly reduced risk of long-term death. Confirming these differences and identifying any potential causal mechanisms await the conduct of appropriately controlled prospective translational trials.","journal":"iScience","year":2020,"id":82435,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9589,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":363548,"name":"Xianghong Zhang","orcid":"0000-0001-5331-9590","position":1,"is_corresponding":false},{"id":424992,"name":"Oscar C. Marroquin","orcid":"0000-0002-0909-0319","position":2,"is_corresponding":false},{"id":425598,"name":"Michael B. Garver","orcid":null,"position":3,"is_corresponding":false},{"id":425599,"name":"AnnaElaine L. Rosengart","orcid":null,"position":4,"is_corresponding":false},{"id":289764,"name":"Chung‐Chou H. Chang","orcid":"0000-0003-3665-6928","position":5,"is_corresponding":false},{"id":422238,"name":"Hamed Esfandiari","orcid":"0000-0001-7301-7047","position":6,"is_corresponding":false},{"id":402692,"name":"Nils A. Loewen","orcid":"0000-0001-7167-1213","position":7,"is_corresponding":false},{"id":347797,"name":"Matthew R. Rosengart","orcid":"0000-0001-9203-5478","position":8,"is_corresponding":false},{"id":363549,"name":"John E. Griepentrog","orcid":"0000-0002-0434-4383","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-18T21:53:19.932222Z","pmid":"33490917","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}