{"doi":"10.1016/j.isci.2020.100928","title":"FAM13A Represses AMPK Activity and Regulates Hepatic Glucose and Lipid Metabolism","abstract":"Obesity commonly co-exists with fatty liver disease with increasing health burden worldwide. Family with Sequence Similarity 13, Member A (FAM13A) has been associated with lipid levels and fat mass by genome-wide association studies (GWAS). However, the function of FAM13A in maintaining metabolic homeostasis in vivo remains unclear. Here, we demonstrated that rs2276936 in this locus has allelic-enhancer activity in massively parallel reporter assays (MPRA) and reporter assay. The DNA region containing rs2276936 regulates expression of endogenous FAM13A in HepG2 cells. In vivo, Fam13a−/− mice are protected from high-fat diet (HFD)-induced fatty liver accompanied by increased insulin sensitivity and reduced glucose production in liver. Mechanistically, loss of Fam13a led to the activation of AMP-activated protein kinase (AMPK) and increased mitochondrial respiration in primary hepatocytes. These findings demonstrate that FAM13A mediates obesity-related dysregulation of lipid and glucose homeostasis. Targeting FAM13A might be a promising treatment of obesity and fatty liver disease.","journal":"iScience","year":2020,"id":103789,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9554,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":255510,"name":"Yae-Huei Liou","orcid":"0000-0001-6758-7318","position":1,"is_corresponding":false},{"id":504978,"name":"Yujun Li","orcid":"0000-0002-1011-0452","position":2,"is_corresponding":false},{"id":504979,"name":"Lu Gong","orcid":"0000-0002-1245-0506","position":3,"is_corresponding":false},{"id":291745,"name":"Yan Li","orcid":"0000-0003-1813-8115","position":4,"is_corresponding":false},{"id":504980,"name":"Yuan Hao","orcid":"0000-0003-2322-6806","position":5,"is_corresponding":false},{"id":505735,"name":"Betty Pham","orcid":null,"position":6,"is_corresponding":false},{"id":392963,"name":"Shuang Xu","orcid":"0000-0002-3262-8500","position":7,"is_corresponding":false},{"id":504981,"name":"Zhiqiang Jiang","orcid":"0009-0004-8833-1361","position":8,"is_corresponding":false},{"id":504982,"name":"Lijia Li","orcid":"0000-0002-8774-7515","position":9,"is_corresponding":false},{"id":85506,"name":"Yifan Peng","orcid":"0000-0001-9309-8331","position":10,"is_corresponding":false},{"id":24856,"name":"Dandi Qiao","orcid":"0000-0001-9450-205X","position":11,"is_corresponding":false},{"id":24806,"name":"Honghuang Lin","orcid":"0000-0003-3043-3942","position":12,"is_corresponding":false},{"id":484232,"name":"Pengda Liu","orcid":"0000-0003-2755-3601","position":13,"is_corresponding":false},{"id":231158,"name":"Wenyi Wei","orcid":"0000-0003-0512-3811","position":14,"is_corresponding":false},{"id":504983,"name":"Guo Zhang","orcid":"0000-0003-0841-4710","position":15,"is_corresponding":false},{"id":255517,"name":"Chih‐Hao Lee","orcid":"0000-0002-6090-0786","position":16,"is_corresponding":false},{"id":416166,"name":"Xiaobo Zhou","orcid":"0000-0002-7127-2869","position":17,"is_corresponding":false},{"id":504977,"name":"Xin Lin","orcid":"0000-0001-5733-6769","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-18T22:42:48.999009Z","pmid":"32151973","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}