{"doi":"10.1016/j.intimp.2025.115745","title":"Integrated time-course metabolomics and dynamic network analysis reveals stage-specific regulation of arachidonic acid and bile acid metabolism in influenza-associated pneumonitis and enteritis","abstract":null,"journal":"International Immunopharmacology","year":2025,"id":629449,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1630167,"name":"Qingyun Ma","orcid":null,"position":1,"is_corresponding":false},{"id":756065,"name":"Jing Liu","orcid":"0000-0002-3588-2969","position":2,"is_corresponding":false},{"id":1630168,"name":"Qihui Sun","orcid":null,"position":3,"is_corresponding":false},{"id":908412,"name":"Zhuangzhuang Li","orcid":"0000-0002-5582-2357","position":4,"is_corresponding":false},{"id":533515,"name":"Yong Yang","orcid":"0000-0002-9928-7165","position":5,"is_corresponding":false},{"id":973788,"name":"Rong Rong","orcid":"0000-0002-3289-4921","position":6,"is_corresponding":false},{"id":590517,"name":"Chen Liu","orcid":"0000-0003-1558-6836","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Integrated time-course metabolomics and dynamic network analysis reveals stage-specific regulation of arachidonic acid and bile acid metabolism in influenza-associated pneumonitis and enteritis","abstract":"The influenza virus, primarily causing respiratory issues, often triggers gastrointestinal symptoms, hinting at a complex lung-gut inflammatory crosstalk. Despite its clinical significance, the timing and mechanisms underlying this intersystem inflammation remain elusive. Leveraging a mouse model of influenza-induced pneumonitis and enteritis, we integrated time-course metabolomics with dynamic network biomarker (DNB) analysis to uncover pivotal transitions and potential molecular mechanisms. Two critical tipping points were identified at 1-2 days post-infection (dpi) and 6 dpi, after which the disease course markedly shifted. Metabolite clustering highlighted significant alterations in arachidonic acid (AA) metabolism at 1-2 dpi, implicating its likely involvement in modulating pulmonary and intestinal inflammation. By 6 dpi, prominent changes in both AA and bile acid (BA) metabolism were observed, suggesting the potential existence of an inflammatory feedback loop that may amplify systemic inflammation. Receiver operating characteristic (ROC) analysis revealed that 16 AA and BA metabolites (AUC > 0.7) have diagnostic potential as biomarkers. These findings demonstrate the stage-specific regulatory roles of AA and BA metabolism during influenza progression. Our study provides new evidence supporting a model of cross-system inflammatory mechanism linking influenza-induced pneumonia to secondary enteritis, laying the foundation for the development of early detection and precise intervention strategies.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41151487","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Natural Science Foundation of Shandong Province","grant_id":"ZR2021LZY012","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"JNSX2023054","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82274397","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"YDZX2023044","title":null}],"total_grants":4,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1567576925017333?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1567576925017333?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Lung","Animals","Mice, Inbred BALB C","Mice, Inbred C57BL","Humans","Mice","Orthomyxoviridae Infections","Enteritis","Pneumonia","Disease Models, Animal","Bile Acids and Salts","Arachidonic Acid","Female","Influenza, Human","Metabolomics","Biomarkers"],"keywords":["Influenza Virus","Arachidonic acid metabolism","Bile Acid Metabolism","Dynamic Network Biomarker","Lung-Gut Crosstalk"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T18:41:06.376409Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}