{"doi":"10.1016/j.intimp.2025.115273","title":"A small-molecule compound cocktail for tumor reprogramming therapy for breast cancer","abstract":null,"journal":"International Immunopharmacology","year":2025,"id":628361,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1488709,"name":"Rui Huang","orcid":"0009-0001-0126-3086","position":1,"is_corresponding":false},{"id":1515027,"name":"Jie Kong","orcid":null,"position":2,"is_corresponding":false},{"id":1626822,"name":"Maojia Wang","orcid":null,"position":3,"is_corresponding":false},{"id":1422198,"name":"Hao Yang","orcid":"0000-0002-6997-6963","position":4,"is_corresponding":false},{"id":1626823,"name":"Hongli Yan","orcid":null,"position":5,"is_corresponding":false},{"id":242218,"name":"Hao Chen","orcid":"0000-0002-8874-0673","position":6,"is_corresponding":false},{"id":668327,"name":"Yong Han","orcid":"0000-0002-4741-9058","position":7,"is_corresponding":false},{"id":1626824,"name":"Junjian Li","orcid":null,"position":8,"is_corresponding":false},{"id":1326027,"name":"Zhenyu Wang","orcid":"0009-0007-7927-6753","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A small-molecule compound cocktail for tumor reprogramming therapy for breast cancer","abstract":"The emergence of lineage reprogramming technology has enabled us to reprogram terminally differentiated somatic cells into other lineages. Tumor cells can reduce malignancy and even restore the function of benign cells through reprogramming technology. Establishing a tumor reprogramming system to induce tumor cell fate transformation and reduce malignancy provides a new strategy for tumor treatment. In this study, we rapidly reprogrammed breast cancer cells with novel cocktails of small-molecule compounds, and their proliferation, metastasis, tumorigenicity, and malignancy were significantly reduced, while drug sensitivity increased, both in vitro and in vivo. Mechanistically, the cocktail may promote the transition of breast cancer cells to Luminal subtype by downregulating the stemness-related gene TSPAN8. In summary, our results suggest that chemically induced reprogramming may be effective in the treatment of breast cancer.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40743622","pmcid":null,"openalex_id":"https://openalex.org/W4412738963","authors":[],"funders":[],"total_grants":0,"fwci":0.508,"citation_percentile":0.66632824,"influential_citations":0,"citation_trend":[{"year":2025,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1567576925012639?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1567576925012639?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.intimp.2025.115273","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40743622","host_type":"repository"}],"fields_of_study":["Cancer Cells and Metastasis","Pluripotent Stem Cells Research","Microtubule and mitosis dynamics","Humans","Breast Neoplasms","Female","Animals","Cellular Reprogramming","Cell Line, Tumor","Mice","Cell Proliferation","Tetraspanins","Small Molecule Libraries","Xenograft Model Antitumor Assays","Antineoplastic Agents","Neoplastic Stem Cells","Mice, Nude"],"mesh_terms":["Animals","Antineoplastic Agents","Breast Neoplasms","Female","Humans","Mice, Nude","Neoplastic Stem Cells","Xenograft Model Antitumor Assays","Cell Line, Tumor","Cell Proliferation","Mice","Small Molecule Libraries","Tetraspanins","Cellular Reprogramming"],"keywords":["Reprogramming","Breast cancer","Cancer therapy","Cancer","Cancer research","Medicine","Oncology","Internal medicine","Biology","Genetics","Gene","Differentiation therapy","Small Molecule","Cancer Cell Reprogramming","Tspan8","Chemical Reprogramming"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T13:12:18.884282Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}