{"doi":"10.1016/j.intimp.2024.113627","title":"The gut-reproductive axis: Bridging microbiota balances to reproductive health and fetal development","abstract":null,"journal":"International Immunopharmacology","year":2025,"id":644711,"datarank":0.6228464565709355,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"self_citation_contribution":0.5101796072493234,"citation_network_contribution":0.11266684932161203,"self_endowment_contribution":0.5101796072493234,"citer_contribution":0.11266684932161203,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":25,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":305223,"name":"Yan Xiong","orcid":"0000-0003-0676-8267","position":1,"is_corresponding":false},{"id":456133,"name":"Dong Guo","orcid":"0000-0002-1055-482X","position":2,"is_corresponding":false},{"id":594527,"name":"Guohong Deng","orcid":"0000-0003-1263-7220","position":3,"is_corresponding":false},{"id":51024,"name":"Haibo Wu","orcid":"0000-0003-0817-9191","position":4,"is_corresponding":false},{"id":1678267,"name":"Bohao Li","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The gut-reproductive axis: Bridging microbiota balances to reproductive health and fetal development","abstract":"The gut microbiota is a highly complex microbial community residing in the digestive tract of humans and animals, closely linked to host health. Dysbiosis within the gut microbiota has been associated with various diseases. Moreover, it interacts with the female reproductive system's microbiota, influencing maternal reproductive homeostasis. Although the gut microbiota holds potential for treating reproductive system diseases and modulating offspring fertility, research in this domain remains limited. This review examines the relationship between both balanced and imbalanced gut microbiota and reproductive system diseases, as well as their effects on fetal development. It is highlighted that dysbiosis in the gut microbiota may contribute to several reproductive conditions, including polycystic ovary syndrome (PCOS), preeclampsia (PE), endometriosis, gestational diabetes, and reproductive cancers. The abundance of specific gut microbial species or interactions among various species can influence the reproductive system through hormonal pathways and other mechanisms, ultimately affecting pregnancy outcomes and fetal health. Therefore, the concept of the gut-reproductive axis is proposed, emphasizing the significant role of maternal gut microbiota in shaping fetal development, metabolic capacity, and immunity.","is_dataset_classified":null,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39579544","pmcid":null,"openalex_id":"https://openalex.org/W4404630705","authors":[],"funders":[{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"2019CDYGZD009","title":null},{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"2020CDJYGRH-1005","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82000020","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81970008","title":null},{"funder_name":"Chongqing Youth Science and Technology Talent Training Project","grant_id":"","title":null}],"total_grants":5,"fwci":4.0012,"citation_percentile":0.95102712,"influential_citations":0,"citation_trend":[{"year":2025,"count":8},{"year":2026,"count":17}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1567576924021490?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1567576924021490?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.intimp.2024.113627","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39579544","host_type":"repository"}],"fields_of_study":["Gut microbiota and health","Pelvic floor disorders treatments","Birth, Development, and Health","Humans","Pregnancy","Gastrointestinal Microbiome","Female","Animals","Fetal Development","Reproductive Health","Dysbiosis","Reproduction"],"mesh_terms":["Gastrointestinal Microbiome","Animals","Female","Humans","Pregnancy","Reproduction","Fetal Development","Reproductive Health","Dysbiosis"],"keywords":["Bridging (networking)","Biology","Gut flora","Reproductive health","Gut–brain axis","Reproductive tract","Physiology","Immunology","Medicine","Environmental health","Endocrinology","Computer science","Population","Pathogenic bacteria","Probiotics","Offspring","Gut Microbiota","Reproductive Balance"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T01:52:26.409085Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}