{"doi":"10.1016/j.intimp.2023.110556","title":"Besides TLR2 and TLR4, NLRP3 is also involved in regulating Escherichia coli infection-induced inflammatory responses in mice","abstract":null,"journal":"International Immunopharmacology","year":2023,"id":592360,"datarank":0.7462207042755109,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.24639002774923022,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.24639002774923022,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":17,"citers_with_citation_signal":11,"citers_with_endowment":11,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":130659,"name":"Zhiguo Gong","orcid":null,"position":1,"is_corresponding":false},{"id":1515739,"name":"Shuangyi Zhang","orcid":null,"position":2,"is_corresponding":false},{"id":1515740,"name":"Jinshan Cao","orcid":null,"position":3,"is_corresponding":false},{"id":1515741,"name":"Wei Mao","orcid":"0000-0003-4181-9787","position":4,"is_corresponding":false},{"id":1208608,"name":"Yuan Yao","orcid":"0000-0002-2620-0794","position":5,"is_corresponding":false},{"id":1515742,"name":"Jiamin Zhao","orcid":null,"position":6,"is_corresponding":false},{"id":983239,"name":"Qianru Li","orcid":"0000-0002-2642-9214","position":7,"is_corresponding":false},{"id":1494003,"name":"Kun Liu","orcid":"0000-0003-1366-4546","position":8,"is_corresponding":false},{"id":618847,"name":"Bo Liu","orcid":"0000-0002-5008-296X","position":9,"is_corresponding":false},{"id":16066,"name":"Shuang Feng","orcid":"0000-0001-7569-2150","position":10,"is_corresponding":false},{"id":1196309,"name":"Yuan Shen","orcid":"0000-0002-9396-1964","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Besides TLR2 and TLR4, NLRP3 is also involved in regulating Escherichia coli infection-induced inflammatory responses in mice","abstract":"The host Toll-like Receptor-2 (TLR2) and Toll-like Receptor-4 (TLR4) play critical roles in defense against Escherichia coli ( E. coli ) infection is well-known. The NLR pyrin domain-containing 3 (NLRP3) inflammasome is also an important candidate during the host-recognized pathogen, while the roles of NLRP3 in the host inflammatory response to E. coli infection remains unclear. This study aimed to explore the roles of NLRP3 in regulating the inflammatory response in E. coli infection-induced mice. Our result indicated that compared to wild-type mice, the TLR2-deficient (TLR2 -/- ), TLR4-deficient (TLR4 -/- ), and NLRP3-deficient (NLRP3 -/- ) mice had significant decrease in liver damage after stimulation with Lipopolysaccharide (LPS, 1 μg/mL), Braun lipoprotein (BLP, 1 μg/mL), or infected by WT E. coli (1 × 10 7 CFU, MOI 5:1) . Meanwhile, compared with wild-type mice, the TNF-α and IL-1β production in serum decreased in TLR2 -/- , TLR4 -/- , and NLRP3 -/- mice after LPS, BLP treatment, or WT E. coli infection. In macrophages from NLRP3 -/- mice showed significantly reduced secretion of TNF-α and IL-1β in response to stimulation with LPS, BLP, or WT E. coli infection compared with macrophages from wild-type mice. These results indicate that besides TLR2 and TLR4, NLRP3 also plays a critical role in host inflammatory responses to defense against E. coli infection, and might provide a therapeutic target in combating disease with bacterium infection.","is_dataset_classified":null,"base_score":3.332204510175204,"endowment":3.332204510175204,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37364329","pmcid":null,"openalex_id":"https://openalex.org/W4381989239","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"32160854","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"32202879","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"32260903","title":null},{"funder_name":"Natural Science Foundation of Inner Mongolia Autonomous Region","grant_id":"2021BS03020","title":null}],"total_grants":4,"fwci":2.4759,"citation_percentile":0.90439718,"influential_citations":0,"citation_trend":[{"year":2023,"count":2},{"year":2024,"count":15},{"year":2025,"count":7},{"year":2026,"count":3}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.intimp.2023.110556","host_type":"journal"},{"url":"https://doi.org/10.1016/j.intimp.2023.110556","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1567576923008792?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1567576923008792?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37364329","host_type":"repository"}],"fields_of_study":["Immune Response and Inflammation","Inflammasome and immune disorders","Immune cells in cancer","Animals","Mice","Escherichia coli","Escherichia coli Infections","Lipopolysaccharides","NLR Family, Pyrin Domain-Containing 3 Protein","Toll-Like Receptor 2","Toll-Like Receptor 4","Tumor Necrosis Factor-alpha"],"mesh_terms":["NLR Family, Pyrin Domain-Containing 3 Protein","Animals","Escherichia coli","Escherichia coli Infections","Lipopolysaccharides","Tumor Necrosis Factor-alpha","Toll-Like Receptor 2","Toll-Like Receptor 4","Mice"],"keywords":["TLR2","TLR4","Pyrin domain","Inflammasome","Escherichia coli infection","Escherichia coli","Lipopolysaccharide","Toll-like receptor","Microbiology","Biology","Receptor","Stimulation","Innate immune system","Immunology","Pathogen","Inflammation","Immune system","Biochemistry","Endocrinology","Gene","Inflammatory Response","Nlrp3"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T13:20:25.895057Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}