{"doi":"10.1016/j.intimp.2022.109005","title":"Roles of Interleukin-6-mediated immunometabolic reprogramming in COVID-19 and other viral infection-associated diseases","abstract":null,"journal":"International Immunopharmacology","year":2022,"id":675840,"datarank":0.9487805232643385,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":0.4544049933636891,"self_endowment_contribution":0.4943755299006494,"citer_contribution":0.4544049933636891,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":26,"citers_with_citation_signal":20,"citers_with_endowment":20,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1765873,"name":"Hua-Cheng Ren","orcid":null,"position":1,"is_corresponding":false},{"id":1765874,"name":"Jian-Hua Cao","orcid":"0000-0001-7789-1911","position":2,"is_corresponding":false},{"id":1765872,"name":"Ying-Shuang Li","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Roles of Interleukin-6-mediated immunometabolic reprogramming in COVID-19 and other viral infection-associated diseases","abstract":"Interleukin-6 (IL-6) is a highly pleiotropic glycoprotein factor that can modulate innate and adaptive immunity as well as various aspects of metabolism, including glycolysis, fatty acid oxidation and oxidative phosphorylation. Recently, the expression and release of IL-6 is shown to be significantly increased in numerous diseases related to virus infection, and this increase is positively correlated with the disease severity. Immunity and metabolism are two highly integrated and interdependent systems, the balance between them plays a pivotal role in maintaining body homeostasis. IL-6-elicited inflammatory response is found to be closely associated with metabolic disorder in patients with viral infection. This brief review summarizes the regulatory role of IL-6 in immunometabolic reprogramming among seven viral infection-associated diseases.","is_dataset_classified":null,"base_score":3.295836866004329,"endowment":3.295836866004329,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35780641","pmcid":"PMC9236983","openalex_id":"https://openalex.org/W4283657894","authors":[],"funders":[],"total_grants":0,"fwci":2.3087,"citation_percentile":0.89759919,"influential_citations":0,"citation_trend":[{"year":2023,"count":6},{"year":2024,"count":8},{"year":2025,"count":7},{"year":2026,"count":5}],"oa_status":"green","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9236983","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9236983","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S1567576922004891?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1567576922004891?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.intimp.2022.109005","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35780641","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9236983","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9236983?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Adipose Tissue and Metabolism","Adrenal Hormones and Disorders","Diabetes and associated disorders","Adaptive Immunity","COVID-19","Communicable Diseases","Glycolysis","Humans","Interleukin-6","Oxidative Phosphorylation"],"mesh_terms":["COVID-19","Communicable Diseases","Glycolysis","Humans","Oxidative Phosphorylation","Interleukin-6","Adaptive Immunity"],"keywords":["Immunity","Biology","Immunology","Reprogramming","Interleukin","Acquired immune system","Inflammation","Immune system","Cytokine","Cell","Biochemistry","Interleukin-6","Viral infection","Covid-19","Immunometabolic Reprogramming"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T01:46:24.184919Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}