{"doi":"10.1016/j.intimp.2016.03.042","title":"Suppression of TLRs signaling pathways by 1-[5-methoxy-2-(2-nitrovinyl)phenyl]pyrrolidine","abstract":null,"journal":"International Immunopharmacology","year":2016,"id":596692,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1180991,"name":"Ji-Soo Kim","orcid":"0000-0003-1571-4762","position":1,"is_corresponding":false},{"id":1528296,"name":"Hyeon-Myeong Shin","orcid":null,"position":2,"is_corresponding":false},{"id":1528297,"name":"Ah-Yeon Kim","orcid":null,"position":3,"is_corresponding":false},{"id":1528298,"name":"Gyo-Jeong Gu","orcid":null,"position":4,"is_corresponding":false},{"id":1528299,"name":"Hyun-Jin Shim","orcid":null,"position":5,"is_corresponding":false},{"id":1184663,"name":"Yeon Joo Kim","orcid":"0000-0003-0116-7681","position":6,"is_corresponding":false},{"id":1528300,"name":"Kwang Oh. Koh","orcid":null,"position":7,"is_corresponding":false},{"id":1528301,"name":"Joo Yang Mang","orcid":null,"position":8,"is_corresponding":false},{"id":199838,"name":"Dae Young Kim","orcid":null,"position":9,"is_corresponding":false},{"id":1528302,"name":"Hyung-Sun Youn","orcid":null,"position":10,"is_corresponding":false},{"id":1528295,"name":"Sang-Il Ahn","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Suppression of TLRs signaling pathways by 1-[5-methoxy-2-(2-nitrovinyl)phenyl]pyrrolidine","abstract":"Toll-like receptors (TLRs) play significant roles in recognizing the pathogen-associated molecular patterns that induce innate immunity, and subsequently, acquired immunity. In general, TLRs have two downstream signaling pathways, the myeloid differential factor 88 (MyD88)-dependent and toll-interleukin-1 receptor domain-containing adapter-inducing interferon-β (TRIF)-dependent pathways, which lead to the activation of nuclear factor-kappa B (NF-κB) and interferon regulatory factor 3 (IRF3). 1-[5-methoxy-2-(2-nitrovinyl)phenyl]pyrrolidine (MNP) has been previously synthesized in our laboratory. To evaluate the therapeutic potential of MNP, its effect on signal transduction via the TLR signaling pathways was examined. MNP was shown to inhibit the activation of NF-κB and IRF3 induced by TLR agonists, as well as to inhibit the expression of cyclooxygenase-2, inducible nitric oxide synthase, and interferon inducible protein-10. MNP also inhibited the activation of NF-κB and IRF3 induced by the overexpression of downstream signaling components of the MyD88- or TRIF-dependent signaling pathways. These results suggest that MNP can modulate MyD88- and TRIF-dependent signaling pathways of TLRs, leading to decreased inflammatory gene expression.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27064546","pmcid":null,"openalex_id":"https://openalex.org/W2340640445","authors":[],"funders":[{"funder_name":"Cooperative Research Program for Agriculture Science & Technology Development","grant_id":"PJ0108262015","title":null}],"total_grants":1,"fwci":0.1409,"citation_percentile":0.53763414,"influential_citations":0,"citation_trend":[{"year":2018,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1567576916301254?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1567576916301254?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.intimp.2016.03.042","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27064546","host_type":"repository"}],"fields_of_study":["Immune Response and Inflammation","NF-κB Signaling Pathways","interferon and immune responses"],"mesh_terms":["RAW 264.7 Cells","Animals","Humans","Immunity, Innate","Nitro Compounds","Pyrrolidines","Signal Transduction","NF-kappa B","Adaptor Proteins, Vesicular Transport","Interferon Regulatory Factor-3","Toll-Like Receptors","Mice","Cyclooxygenase 2","Nitric Oxide Synthase Type II","Myeloid Differentiation Factor 88","Chemokine CXCL10","HEK293 Cells"],"keywords":["TRIF","IRF3","Signal transduction","Interferon regulatory factors","Transcription factor","Cell biology","Toll-like receptor","Innate immune system","Biology","Chemistry","Receptor","Cancer research","Biochemistry","Gene","Nuclear factor-κB","MyD88","1-[5-Methoxy-2-(2-nitrovinyl)phenyl]pyrrolidine"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T11:00:07.832748Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}