{"doi":"10.1016/j.intimp.2015.05.017","title":"Suppression of the TRIF-dependent signaling pathway of Toll-like receptor by CDr10b in RAW264.7 macrophages","abstract":null,"journal":"International Immunopharmacology","year":2015,"id":623465,"datarank":0.3562586549412271,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.06437213258293008,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.06437213258293008,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":1,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1611273,"name":"Sang-il Ahn","orcid":null,"position":1,"is_corresponding":false},{"id":1180991,"name":"Ji-Soo Kim","orcid":"0000-0003-1571-4762","position":2,"is_corresponding":false},{"id":1611286,"name":"Chae-Yeon Hong","orcid":null,"position":3,"is_corresponding":false},{"id":1611290,"name":"Sung-Chan Lee","orcid":null,"position":4,"is_corresponding":false},{"id":189371,"name":"Young-Tae Chang","orcid":null,"position":5,"is_corresponding":false},{"id":995842,"name":"Tae Hyun Choi","orcid":null,"position":6,"is_corresponding":false},{"id":392435,"name":"Byoung Soo Kim","orcid":"0000-0002-4023-7323","position":7,"is_corresponding":false},{"id":1528302,"name":"Hyung-Sun Youn","orcid":null,"position":8,"is_corresponding":false},{"id":1528298,"name":"Gyo-Jeong Gu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Suppression of the TRIF-dependent signaling pathway of Toll-like receptor by CDr10b in RAW264.7 macrophages","abstract":"Toll-like receptors (TLRs) recognize distinct pathogen-associated molecular patterns and play a critical role in innate immune responses. TLR signaling pathways can be largely classified as either myeloid differential factor 88 (MyD88)- or toll-interleukin-1 receptor domain-containing adapter inducing interferon-β (TRIF)-dependent pathways. Compound of Designation red 10 binding (CDr10b) was synthesized to investigate its role in neuroinflammatory diseases. This study was conducted to determine whether CDr10b can affect TLR signaling pathways. CDr10b suppressed NF-κB activation as well as COX-2 and iNOS expression induced by TLR3 or TLR4 agonists. CDr10b also suppressed the activation of interferon regulatory factor 3 (IRF3) and the expression of interferon inducible protein-10 (IP-10) induced by TLR3 or TLR4 agonists. These results indicate that CDr10b can modulate the TRIF-dependent pathway of TLRs and has the potential to become a new therapeutic drug for chronic inflammatory diseases.","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26004315","pmcid":null,"openalex_id":"https://openalex.org/W320525602","authors":[],"funders":[{"funder_name":"Cooperative Research Program for Agriculture Science & Technology Development","grant_id":"PJ0108262015","title":null},{"funder_name":"Soonchunhyang University Research","grant_id":"","title":null}],"total_grants":2,"fwci":0.2526,"citation_percentile":0.53774883,"influential_citations":0,"citation_trend":[{"year":2016,"count":1},{"year":2017,"count":1},{"year":2020,"count":1},{"year":2021,"count":2},{"year":2023,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1567576915002465?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1567576915002465?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.intimp.2015.05.017","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26004315","host_type":"repository"},{"url":"https://oasis.postech.ac.kr/handle/2014.oak/50379","host_type":"repository"}],"fields_of_study":["Immune Response and Inflammation","Immune cells in cancer","NF-κB Signaling Pathways"],"mesh_terms":["RAW 264.7 Cells","Animals","Boron Compounds","Macrophages","Signal Transduction","NF-kappa B","Protein Serine-Threonine Kinases","Adaptor Proteins, Vesicular Transport","Interferon Regulatory Factor-3","Toll-Like Receptors","Toll-Like Receptor 3","Toll-Like Receptor 4","Mice","Cyclooxygenase 2","Nitric Oxide Synthase Type II","Chemokine CXCL10"],"keywords":["TRIF","TLR3","Toll-like receptor","Interferon regulatory factors","IRF3","Signal transduction","TLR4","Innate immune system","Receptor","Interferon","Cell biology","Biology","Immunology","Immune system","Biochemistry","IP-10","Cdr10b"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T23:55:55.631412Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}