{"doi":"10.1016/j.inpsyc.2024.100012","title":"Correlation between changes in apathy and cognition in Alzheimer’s disease associated apathy: Analysis of the Apathy in Dementia Methylphenidate Trial 2 (ADMET 2)","abstract":"BACKGROUND: Previous trials have shown improvements in both apathy and cognition with methylphenidate (MPH). OBJECTIVES: To assess whether changes in apathy correlated with changes in cognition in the Apathy in Dementia Methylphenidate Trial 2 (ADMET 2). PARTICIPANTS: Mild to moderate AD patients with clinically significant apathy randomized to MPH (20 mg/day) or placebo for 6 months. MEASUREMENTS: Apathy was measured with the Neuropsychiatric Inventory-apathy (NPI-A) domain. Cognition was measured using the Mini-Mental State Exam (MMSE), Hopkins Verbal Learning (immediate [HVLT-I], delayed [HVLT-D] recall), Digit Span (Forward [DF], Backward [DB]), Trail Making (TMT-A, TMT-B), Action Verbal Fluency (AV), Category Fluency (CF), and the Short Boston Naming Test (BNT). DESIGN: Linear mixed models included cognitive change scores as dependent variables and time, treatment, change in NPI-A and the interaction between treatment and change in NPI-A as independent variables, which were additionally adjusted for baseline NPI-A and cognitive scores, age, sex, level of education and presence of diabetes. RESULTS: 199 participants (66 % male) were included (98-MPH, 101-placebo). Among all participants, worsening CF was associated with worsening apathy (-0.15 (0.05), p = .003). In addition, change in HVLT-I was associated with the interaction between changes in apathy and treatment (-0.31 (0.07), p = 0.0000158). CONCLUSION: Changes in apathy are mostly independent of cognitive changes and apathy response to MPH may be independent from cognition. These results are consistent with the view that apathy as a syndrome is related to but distinct from cognition.","journal":"International Psychogeriatrics","year":2024,"id":472633,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9191,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":340395,"name":"Shankar Tumati","orcid":"0000-0001-5703-2044","position":1,"is_corresponding":false},{"id":257456,"name":"Jamie Perin","orcid":"0000-0002-5482-6620","position":2,"is_corresponding":false},{"id":1133839,"name":"Luc Rivet","orcid":null,"position":3,"is_corresponding":false},{"id":1133511,"name":"Danielle Soares Rocha Vieira","orcid":"0000-0001-6222-6142","position":4,"is_corresponding":false},{"id":320072,"name":"Paul B. Rosenberg","orcid":"0000-0003-1106-4299","position":5,"is_corresponding":false},{"id":244608,"name":"Nathan Herrmann","orcid":"0000-0001-9277-6110","position":6,"is_corresponding":false},{"id":448226,"name":"David Shade","orcid":null,"position":7,"is_corresponding":false},{"id":233800,"name":"Alan J. Lerner","orcid":"0000-0001-9447-6154","position":8,"is_corresponding":false},{"id":1133512,"name":"Prasad R. Padala","orcid":"0000-0003-1921-9806","position":9,"is_corresponding":false},{"id":1133840,"name":"Olga Brawman‐Mintzer","orcid":null,"position":10,"is_corresponding":false},{"id":235262,"name":"Christopher H. van Dyck","orcid":"0000-0003-1779-097X","position":11,"is_corresponding":false},{"id":231709,"name":"Anton P. Porsteinsson","orcid":"0000-0002-0166-1738","position":12,"is_corresponding":false},{"id":55001,"name":"Suzanne Craft","orcid":"0000-0003-0591-8657","position":13,"is_corresponding":false},{"id":68010,"name":"Allan I. Levey","orcid":"0000-0002-3153-502X","position":14,"is_corresponding":false},{"id":67157,"name":"Jacobo Mintzer","orcid":null,"position":15,"is_corresponding":false},{"id":244604,"name":"Krista L. Lanctôt","orcid":"0000-0001-7024-6637","position":16,"is_corresponding":false},{"id":1133510,"name":"Krushnaa Sankhe","orcid":"0000-0003-0535-4935","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-19T02:05:57.032095Z","pmid":"40086910","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}