{"doi":"10.1016/j.immuno.2023.100022","title":"Modeling interaction of Glioma cells and CAR T-cells considering multiple CAR T-cells bindings","abstract":"Chimeric antigen receptor (CAR) T-cell based immunotherapy has shown its potential in treating blood cancers, and its application to solid tumors is currently being extensively investigated. For glioma brain tumors, various CAR T-cell targets include IL13Rα2, EGFRvIII, HER2, EphA2, GD2, B7-H3, and chlorotoxin. In this work, we are interested in developing a mathematical model of IL13Rα2 targeting CAR T-cells for treating glioma. We focus on extending the work of Kuznetsov et al. (1994) by considering binding of multiple CAR T-cells to a single glioma cell, and the dynamics of these multi-cellular conjugates. Our model more accurately describes experimentally observed CAR T-cell killing assay data than the models which do not consider multi-cellular conjugates. Moreover, we derive conditions in the CAR T-cell expansion rate that determines treatment success or failure. Finally, we show that our model captures distinct CAR T-cell killing dynamics from low to high antigen receptor densities in patient-derived brain tumor cells.","journal":"ImmunoInformatics","year":2023,"id":335933,"datarank":0.4566783656585135,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.0,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9501,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":274013,"name":"Prativa Sahoo","orcid":"0000-0001-9731-5364","position":1,"is_corresponding":false},{"id":249971,"name":"Dongrui Wang","orcid":"0000-0002-0859-7281","position":2,"is_corresponding":false},{"id":703664,"name":"Qixuan Wang","orcid":"0000-0003-2673-921X","position":3,"is_corresponding":false},{"id":249980,"name":"Christine E. Brown","orcid":"0000-0003-4915-8207","position":4,"is_corresponding":false},{"id":274023,"name":"Russell C. Rockne","orcid":"0000-0002-1557-159X","position":5,"is_corresponding":false},{"id":274019,"name":"Heyrim Cho","orcid":"0000-0003-3005-8943","position":6,"is_corresponding":false},{"id":1066373,"name":"Runpeng Li","orcid":null,"position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:10:02.777338Z","pmid":"36875891","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}