{"doi":"10.1016/j.immuni.2026.01.003","title":"Hormonal rewiring of immunity during dietary restriction ensures host defense and systemic glucose conservation","abstract":null,"journal":"Immunity","year":2026,"id":653418,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1255870,"name":"Mingeum Jeong","orcid":"0000-0002-7004-3853","position":1,"is_corresponding":false},{"id":1704922,"name":"Charles Carr","orcid":null,"position":2,"is_corresponding":false},{"id":1704923,"name":"Riley M. 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When food availability is reduced, it is unclear how the host adapts to support glucose-demanding immune processes while preventing hypoglycemia. In the context of dietary restriction (DR), we found that glucocorticoids (GCs) aligned naive, effector, and memory T cell populations with the nutritional status of the host. DR-induced GCs promoted naive T cell homing to the bone marrow, which supported their homeostasis at steady state. Following a primary infection, DR-induced GCs rewired immunity to simultaneously uphold pathogen control and systemic glucose homeostasis. GCs achieved this by dampening effector T cells and enhancing the response of neutrophils with reduced glucose dependence. Although the total effector T cell pool was decreased during DR, GCs enriched memory-precursor effector cells to preserve memory formation. Thus, GCs align immunity and metabolic physiology to ensure host fitness when food availability is reduced.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41672072","pmcid":"PMC13183397","openalex_id":null,"authors":[],"funders":[{"funder_name":"Cancer Research Institute","grant_id":"CRI12557","title":null},{"funder_name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","grant_id":"AI095608","title":null},{"funder_name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","grant_id":"AI095466","title":null},{"funder_name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","grant_id":"AI142213","title":null},{"funder_name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","grant_id":"AI151599","title":null},{"funder_name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","grant_id":"AI172027","title":null},{"funder_name":"National Cancer Institute Division of Cancer Prevention","grant_id":"R00CA252443-03S1","title":null},{"funder_name":"National Institute of Diabetes and Digestive and Kidney Diseases","grant_id":"2023/07482-2","title":null},{"funder_name":"National Institute of Diabetes and Digestive and Kidney Diseases","grant_id":"R01120985","title":null},{"funder_name":"National Institute of Diabetes and Digestive and Kidney Diseases","grant_id":"R01DK114252","title":null},{"funder_name":"National Institute of Diabetes and Digestive and Kidney Diseases","grant_id":"DK132244","title":null},{"funder_name":"National Institute of Diabetes and Digestive and Kidney Diseases","grant_id":"R01128257","title":null},{"funder_name":"National Institute of Diabetes and Digestive and Kidney Diseases","grant_id":"DK126871","title":null},{"funder_name":"Fundação de Amparo à Pesquisa do Estado de São Paulo","grant_id":"2023/01164-9","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI182043","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P30 CA008748","title":null}],"total_grants":16,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"cc-by-nc-nd","oa_locations":[{"url":"https://ecommons.cornell.edu/items/14a50634-6032-4664-9bfb-7e424a3325b6/request-a-copy?bitstream=cd3afe56-07cd-48cf-9978-a1e97eb729a3","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S1074761326000026?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1074761326000026?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13183397/","host_type":"repository"}],"fields_of_study":[],"mesh_terms":["Neutrophils","T-Lymphocytes","Animals","Mice","Glucose","Glucocorticoids","Caloric Restriction","Immunologic Memory","Homeostasis"],"keywords":["Hormones","Metabolism","Nutrition","Glucocorticoids","T cell","Caloric restriction","neutrophil"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"geo"},{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T21:33:52.481509Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}