{"doi":"10.1016/j.immuni.2025.11.020","title":"Positioning and reversible suppression of CCR7+ dendritic cells in perivascular tumor niches shape cancer immunity","abstract":"Tumor-resident CCR7 + dendritic cells (DCs) are key determinants of antitumor T cell responses. Here, we examined the localization of CCR7 + DCs within tumors and the impact of this positioning on antitumor immunity. Spatial, single-cell, and intravital analyses of human cancers and mouse models reveal that CCR7 + DCs form perivascular clusters. Fibroblasts surrounding venous blood vessels produced CCL19, guiding CCR7 + DCs into perivascular niches. Regulatory T (Treg) cells frequently contact perivascular CCR7 + DCs, suppressing CD40 expression and CD4 + and CD8 + T cell activation. Treg cell depletion restored CD40 expression by CCR7 + DCs, enhanced immunostimulatory programs, and improved T cell-dependent tumor control. Anti-PD-1 not only increased perivascular CCR7 + DC clustering and IL-12 production but also strengthened Treg-DC interactions through a CCL22-dependent mechanism, limiting therapeutic efficacy. CCR7 + DCs expressed both co-stimulatory and co-inhibitory molecules, which may underlie their capacity for antitumor activation and concurrent vulnerability to suppression. Modulating the mechanisms that form and restrain CCR7 + DC perivascular immune hubs may improve cancer immunotherapy.","journal":"Immunity","year":2025,"id":513140,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9503,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1013882,"name":"Florent Duval","orcid":"0000-0002-3652-184X","position":1,"is_corresponding":false},{"id":68188,"name":"Pratyaksha Wirapati","orcid":"0000-0002-0327-4686","position":2,"is_corresponding":false},{"id":1014171,"name":"Mehdi Hicham","orcid":"0000-0002-9979-4757","position":3,"is_corresponding":false},{"id":1374154,"name":"Yuxuan Xie","orcid":null,"position":4,"is_corresponding":false},{"id":937177,"name":"Juhyun Oh","orcid":"0000-0002-4492-6978","position":5,"is_corresponding":false},{"id":1013883,"name":"Jan Hoelzl","orcid":"0000-0002-6411-7422","position":6,"is_corresponding":false},{"id":1365511,"name":"Philippa Meiser","orcid":"0009-0007-9334-1072","position":7,"is_corresponding":false},{"id":1013884,"name":"Marco Varrone","orcid":"0000-0002-0538-3464","position":8,"is_corresponding":false},{"id":1374155,"name":"Hannah M. 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