{"doi":"10.1016/j.immuni.2025.09.008","title":"The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8+ T cells","abstract":"During differentiation of CD8 + T cells, the transcription factors TCF-1 and Blimp1 control progenitor and terminally differentiated states, respectively. Here, we examined the hierarchy and functional consequences of cross-regulation between these factors. We identified two Blimp1-bound cis -regulatory elements, Tcf7 +22kb and Tcf7 +17kb , that enforced Tcf7 silencing in a context-specific manner during both acute and chronic responses. Deletion of these elements decoupled Tcf7 repression from effector differentiation but did not rewire effector T cells to a memory state or prevent the acquisition of phenotypic hallmarks of exhaustion. However, combined ablation of Prdm1 and Tcf7 preserved a memory surface phenotype despite defects in secondary expansion. Thus, the anti-proliferative and pro-differentiative effects of Blimp1 in effector or exhausted CD8 + T cells represent mechanistically distinct modules, wherein repression of Tcf7 limits proliferative capacity but not memory or progenitor specification.","journal":"Immunity","year":2025,"id":522164,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9484,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":276877,"name":"Matthew McCullen","orcid":"0000-0001-9138-1483","position":1,"is_corresponding":false},{"id":1282389,"name":"Joshua L. Deffenbaugh","orcid":"0000-0002-5353-5709","position":2,"is_corresponding":false},{"id":820811,"name":"Andy Y. Chen","orcid":"0000-0002-5018-355X","position":3,"is_corresponding":false},{"id":673669,"name":"Joy A. Pai","orcid":"0000-0003-3580-8061","position":4,"is_corresponding":false},{"id":237496,"name":"Bence Dániel","orcid":"0000-0002-2410-8767","position":5,"is_corresponding":false},{"id":1214444,"name":"Amir Yousif","orcid":"0000-0002-7300-1667","position":6,"is_corresponding":false},{"id":564287,"name":"Saravanan Raju","orcid":"0000-0003-3216-5574","position":7,"is_corresponding":false},{"id":417820,"name":"Sunnie Hsiung","orcid":"0000-0002-4813-7220","position":8,"is_corresponding":false},{"id":1393564,"name":"Zhenxiao Wang","orcid":null,"position":9,"is_corresponding":false},{"id":271008,"name":"Hazem E. Ghoneim","orcid":"0000-0002-9816-4286","position":10,"is_corresponding":false},{"id":21653,"name":"Ansuman T. Satpathy","orcid":"0000-0002-5167-537X","position":11,"is_corresponding":false},{"id":71132,"name":"Marco Colonna","orcid":"0000-0001-5222-4987","position":12,"is_corresponding":false},{"id":244459,"name":"Eugene M. Oltz","orcid":"0000-0002-2513-7156","position":13,"is_corresponding":false},{"id":564292,"name":"Takeshi Egawa","orcid":"0000-0001-7489-1051","position":14,"is_corresponding":false},{"id":1393066,"name":"Maegan K Murphy","orcid":"0000-0002-3913-8715","position":0,"is_corresponding":true}],"reference_count":72,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:49:49.198144Z","pmid":"41043414","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}