{"doi":"10.1016/j.immuni.2025.08.014","title":"Integrin CD103 expression in naive CD8+ T cells promotes cytokine-driven acquisition of memory phenotype and effector function","abstract":"Integrin CD103 binds to E-cadherin, a cell adhesion molecule predominantly expressed on epithelial cells, thus mediating the tissue residency of CD103 + T cells in barrier sites. Importantly, circulating naive CD8 + T cells also express large amounts of CD103, but whether CD103 contributes to CD8 + T cell immunity beyond its role in cell adhesion is unclear. Here, we report that CD103 expression in naive CD8 + T cells facilitates their engagement with E-cadherin-expressing cells, promoting their acquisition of memory phenotype and effector function. Notably, dendritic cell (DC) subsets expressing E-cadherin and producing type I interferons and interleukin-12 (IL-12) were responsible for this process. As a corollary, the DC-specific loss of E-cadherin resulted in diminished effector CD8 + T cell differentiation and increased tumor susceptibility, while the forced expression of CD103 enhanced the effector functions and anti-tumor activity of CD8 + T cells, revealing a regulatory role for CD103 in cytotoxic T cell immunity.","journal":"Immunity","year":2025,"id":514045,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9466,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":751203,"name":"Davinna L. Ligons","orcid":"0000-0002-5065-9589","position":1,"is_corresponding":false},{"id":1259894,"name":"Dominic Lanasa","orcid":null,"position":2,"is_corresponding":false},{"id":399862,"name":"Hilary R. Keller","orcid":"0000-0002-6510-5685","position":3,"is_corresponding":false},{"id":401028,"name":"Megan A. Luckey","orcid":null,"position":4,"is_corresponding":false},{"id":348875,"name":"Brian J. Capaldo","orcid":"0000-0003-1244-8884","position":5,"is_corresponding":false},{"id":418276,"name":"Daoud Meerzaman","orcid":"0000-0002-0129-5256","position":6,"is_corresponding":false},{"id":736323,"name":"Joo‐Young Park","orcid":"0000-0002-0333-6349","position":7,"is_corresponding":false},{"id":399865,"name":"Jung‐Hyun Park","orcid":"0000-0002-9547-9055","position":8,"is_corresponding":false},{"id":751204,"name":"Can Li","orcid":"0000-0002-8420-120X","position":0,"is_corresponding":true}],"reference_count":100,"raw_metadata":null,"created_at":"2026-07-19T02:48:23.284782Z","pmid":"40957420","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}