{"doi":"10.1016/j.immuni.2024.11.021","title":"Durable lymphocyte subset elimination upon a single dose of AAV-delivered depletion antibody dissects immune control of chronic viral infection","abstract":"To interrogate the role of specific immune cells in infection, cancer, and autoimmunity, immunologists commonly use monoclonal depletion antibodies (depletion-mAbs) or genetically engineered mouse models (GEMMs). To generate a tool that combines specific advantages and avoids select drawbacks of the two methods, we engineered adeno-associated viral vectors expressing depletion mAbs (depletion-AAVs). Single-dose depletion-AAV administration durably eliminated lymphocyte subsets in mice and avoided accessory deficiencies of GEMMs, such as marginal zone defects in B cell-deficient animals. Depletion-AAVs can be used in animals of different genetic backgrounds, and multiple depletion-AAVs can readily be combined. Exploiting depletion-AAV technology, we showed that B cells were required for unimpaired CD4 + and CD8 + T cell responses to chronic lymphocytic choriomeningitis virus (LCMV) infection. Upon B cell depletion, CD8 + T cells failed to suppress viremia, and they only helped resolve chronic infection when antibodies dampened viral loads. Our study positions depletion-AAVs as a versatile tool for immunological research.","journal":"Immunity","year":2024,"id":429479,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9529,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1231612,"name":"Anna‐Friederike Marx","orcid":"0009-0005-4569-3829","position":1,"is_corresponding":false},{"id":1232161,"name":"Mirela Dimitrova","orcid":null,"position":2,"is_corresponding":false},{"id":703428,"name":"Tiago Abreu-Mota","orcid":"0000-0002-0891-4734","position":3,"is_corresponding":false},{"id":1231613,"name":"Yusuf I. Ertuna","orcid":"0000-0002-7714-0605","position":4,"is_corresponding":false},{"id":1232162,"name":"Weldy V. Bonilla","orcid":null,"position":5,"is_corresponding":false},{"id":1232163,"name":"Karsten Stauffer","orcid":null,"position":6,"is_corresponding":false},{"id":984196,"name":"Marco Künzli","orcid":"0000-0001-7699-779X","position":7,"is_corresponding":false},{"id":1231614,"name":"Ingrid Wagner","orcid":"0000-0003-4437-9799","position":8,"is_corresponding":false},{"id":1231615,"name":"Mario Kreutzfeldt","orcid":"0000-0003-0335-2733","position":9,"is_corresponding":false},{"id":644577,"name":"Doron Merkler","orcid":"0000-0002-0247-2007","position":10,"is_corresponding":false},{"id":1231616,"name":"Daniel D. Pinschewer","orcid":"0000-0002-1594-3189","position":11,"is_corresponding":false},{"id":1232160,"name":"Anna Lena Kastner","orcid":null,"position":0,"is_corresponding":true}],"reference_count":146,"raw_metadata":null,"created_at":"2026-07-19T01:59:06.668462Z","pmid":"39719711","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}