{"doi":"10.1016/j.immuni.2024.07.011","title":"Microglia in the hypothalamic paraventricular nucleus sense hemodynamic disturbance and promote sympathetic excitation in hypertension","abstract":null,"journal":"Immunity","year":2024,"id":654257,"datarank":0.5533319181170905,"base_score":3.6888794541139363,"endowment":3.6888794541139363,"self_citation_contribution":0.5533319181170905,"citation_network_contribution":0.0,"self_endowment_contribution":0.5533319181170905,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":39,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":42074,"name":"Guo Cheng","orcid":"0000-0002-8045-5843","position":1,"is_corresponding":false},{"id":1707459,"name":"Qianqian Bi","orcid":null,"position":2,"is_corresponding":false},{"id":297606,"name":"Cheng Lu","orcid":"0000-0002-7651-3924","position":3,"is_corresponding":false},{"id":1707460,"name":"Qihang Sun","orcid":null,"position":4,"is_corresponding":false},{"id":697735,"name":"Li Li","orcid":"0000-0001-6598-6358","position":5,"is_corresponding":false},{"id":1707461,"name":"Ningting Chen","orcid":null,"position":6,"is_corresponding":false},{"id":1707462,"name":"Miner Hu","orcid":null,"position":7,"is_corresponding":false},{"id":1266624,"name":"Haoran Lu","orcid":"0009-0005-8829-2232","position":8,"is_corresponding":false},{"id":1707463,"name":"Xuancheng Xu","orcid":null,"position":9,"is_corresponding":false},{"id":497404,"name":"Genxiang Mao","orcid":"0000-0001-7061-4479","position":10,"is_corresponding":false},{"id":454724,"name":"Shu Wan","orcid":"0000-0001-9455-5629","position":11,"is_corresponding":false},{"id":1707465,"name":"Zhechun Hu","orcid":null,"position":12,"is_corresponding":false},{"id":1491889,"name":"Yan Gu","orcid":"0000-0002-5637-5480","position":13,"is_corresponding":false},{"id":655349,"name":"Jiaxin Zheng","orcid":"0000-0001-5943-0935","position":14,"is_corresponding":false},{"id":1438887,"name":"Li Zhao","orcid":"0000-0003-1576-8787","position":15,"is_corresponding":false},{"id":1707467,"name":"Xiao Z. Shen","orcid":null,"position":16,"is_corresponding":false},{"id":217152,"name":"Xiaoli Liu","orcid":"0000-0003-4810-1815","position":17,"is_corresponding":false},{"id":917405,"name":"Peng Shi","orcid":"0000-0001-8406-106X","position":18,"is_corresponding":false},{"id":1234972,"name":"Bo Wei","orcid":"0000-0002-8261-123X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Microglia in the hypothalamic paraventricular nucleus sense hemodynamic disturbance and promote sympathetic excitation in hypertension","abstract":"Hypertension is usually accompanied by elevated sympathetic tonicity, but how sympathetic hyperactivity is triggered is not clear. Recent advances revealed that microglia-centered neuroinflammation contributes to sympathetic excitation in hypertension. In this study, we performed a temporospatial analysis of microglia at both morphological and transcriptomic levels and found that microglia in the hypothalamic paraventricular nucleus (PVN), a sympathetic center, were early responders to hypertensive challenges. Vasculature analyses revealed that the PVN was characterized by high capillary density, thin vessel diameter, and complex vascular topology relative to other brain regions. As such, the PVN was susceptible to the penetration of ATP released from the vasculature in response to hemodynamic disturbance after blood pressure increase. Mechanistically, ATP ligation to microglial P2Y12 receptor was responsible for microglial inflammatory activation and the eventual sympathetic overflow. Together, these findings identified a distinct vasculature pattern rendering vulnerability of PVN pre-sympathetic neurons to hypertension-associated microglia-mediated inflammatory insults.","is_dataset_classified":null,"base_score":3.6888794541139363,"endowment":3.6888794541139363,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39116878","pmcid":null,"openalex_id":"https://openalex.org/W4401391279","authors":[],"funders":[{"funder_name":"Science and Technology Department of Zhejiang Province","grant_id":"2021C03105","title":null},{"funder_name":"Science and Technology Program of Zhejiang Province","grant_id":"LGJ22H180004","title":null},{"funder_name":"China Postdoctoral Science Foundation","grant_id":"BX20230318","title":null},{"funder_name":"China Postdoctoral Science Foundation","grant_id":"2023M733092","title":null},{"funder_name":"Alzheimer's Association","grant_id":"AARF-18-566347","title":null},{"funder_name":"Natural Science Foundation of Zhejiang Province","grant_id":"LZ22C080001","title":null},{"funder_name":"Natural Science Foundation of Zhejiang Province","grant_id":"LY24H250003","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"31970898","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82188102","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"32170894","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82170441","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"32300800","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82371252","title":null},{"funder_name":"Zhejiang Administration Bureau of Traditional Chinese Medicine","grant_id":"2022ZA004","title":null}],"total_grants":14,"fwci":6.4109,"citation_percentile":0.97346345,"influential_citations":0,"citation_trend":[{"year":2024,"count":3},{"year":2025,"count":19},{"year":2026,"count":17}],"oa_status":"bronze","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"http://www.cell.com/article/S1074761324003601/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S1074761324003601/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1074761324003601?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1074761324003601?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.immuni.2024.07.011","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39116878","host_type":"repository"}],"fields_of_study":["Neuroinflammation and Neurodegeneration Mechanisms","Regulation of Appetite and Obesity","Stress Responses and Cortisol","Paraventricular Hypothalamic Nucleus","Animals","Microglia","Hypertension","Mice","Hemodynamics","Sympathetic Nervous System","Male","Mice, Inbred C57BL","Adenosine Triphosphate","Receptors, Purinergic P2Y12","Inflammation","Blood Pressure","Neurons"],"mesh_terms":["Adenosine Triphosphate","Animals","Blood Pressure","Hemodynamics","Hypertension","Inflammation","Male","Mice, Inbred C57BL","Neurons","Paraventricular Hypothalamic Nucleus","Sympathetic Nervous System","Microglia","Mice","Receptors, Purinergic P2Y12"],"keywords":["Microglia","Neuroinflammation","Hypothalamus","Internal medicine","Nucleus","Endocrinology","Hemodynamics","Sympathetic nervous system","Biology","Blood pressure","Inflammation","Neuroscience","Medicine","ATP","P2Y(12)","cerebral blood perfusion","hypertension","hypothalamic paraventricular nucleus","sympathetic nerve activity"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T05:18:08.000757Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}