{"doi":"10.1016/j.immuni.2023.03.010","title":"CD8+ T cells promote HIV latency by remodeling CD4+ T cell metabolism to enhance their survival, quiescence, and stemness","abstract":"HIV infection persists during antiretroviral therapy (ART) due to a reservoir of latently infected cells that harbor replication-competent virus and evade immunity. Previous ex vivo studies suggested that CD8 + T cells from people with HIV may suppress HIV expression via non-cytolytic mechanisms, but the mechanisms responsible for this effect remain unclear. Here, we used a primary cell-based in vitro latency model and demonstrated that co-culture of autologous activated CD8 + T cells with HIV-infected memory CD4 + T cells promoted specific changes in metabolic and/or signaling pathways resulting in increased CD4 + T cell survival, quiescence, and stemness. Collectively, these pathways negatively regulated HIV expression and ultimately promoted the establishment of latency. As shown previously, we observed that macrophages, but not B cells, promoted latency in CD4 + T cells. The identification of CD8-specific mechanisms of pro-latency activity may favor the development of approaches to eliminate the viral reservoir in people with HIV.","journal":"Immunity","year":2023,"id":322146,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9567,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":266645,"name":"Talia M. Mota","orcid":"0000-0002-8925-0158","position":1,"is_corresponding":false},{"id":248734,"name":"Lavinia Franchitti","orcid":null,"position":2,"is_corresponding":false},{"id":468256,"name":"Ashish Sharma","orcid":"0000-0001-9444-7046","position":3,"is_corresponding":false},{"id":1035531,"name":"Abigail Willemse","orcid":"0000-0001-9284-4793","position":4,"is_corresponding":false},{"id":1036356,"name":"Sydney N. Bergstresser","orcid":null,"position":5,"is_corresponding":false},{"id":233134,"name":"Hong Wang","orcid":"0000-0001-6258-4070","position":6,"is_corresponding":false},{"id":466905,"name":"Maura Statzu","orcid":"0000-0003-0070-2195","position":7,"is_corresponding":false},{"id":244967,"name":"Gregory K. Tharp","orcid":"0000-0003-3075-755X","position":8,"is_corresponding":false},{"id":874861,"name":"Jared Weiler","orcid":"0000-0001-8347-839X","position":9,"is_corresponding":false},{"id":244983,"name":"Rafick‐Pierre Sékaly","orcid":"0000-0002-7816-4828","position":10,"is_corresponding":false},{"id":232942,"name":"Steven E. Bosinger","orcid":"0000-0002-2116-5061","position":11,"is_corresponding":false},{"id":244985,"name":"Mirko Paiardini","orcid":"0000-0002-7276-3600","position":12,"is_corresponding":false},{"id":233497,"name":"Guido Silvestri","orcid":"0000-0001-6602-2470","position":13,"is_corresponding":false},{"id":95313,"name":"R. Brad Jones","orcid":"0000-0003-4470-1231","position":14,"is_corresponding":false},{"id":247225,"name":"Deanna A. Kulpa","orcid":"0000-0002-0411-7295","position":15,"is_corresponding":false},{"id":1035530,"name":"Simona Mutascio","orcid":"0000-0002-0542-748X","position":0,"is_corresponding":true}],"reference_count":103,"raw_metadata":null,"created_at":"2026-07-19T01:07:42.497873Z","pmid":"37030290","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}